FEB 05, 2014 5:00 PM PST

Designing a health - monitoring programme for laboratory mice

Speaker
  • Director of Animal Facilities, Garvan Institute of Medical Research, Australia
    Biography

       
      Dr Jenny Kingham is a veterinarian, with 25 years experience in the management and design of laboratory animal facilities. She is Director of Animal Facilities at the Garvan Institute of Medical Research inSydney, Australia and is CEO of the Australian BioResources facility. Dr Kingham's special interest is in management of Specific Pathogen Free animal facilities and the care of genetically modified mice.
       

    Abstract

    Monitoring the health of laboratory rodents is an important tool for improving the quality of animals used in research. However not all animal facilities have the same requirements, and an extensive health screen is not always warranted. Large breeding facilities supplying rodents to multiple institutes are under greater pressure to validate the health status of their colonies than experimental facilities holding rodents for short-term experiments. The biosecurity of the facility and the ability to quarantine and/or rederive imported rodents will impact on the likelihood of a facility remaining pathogen free. The value of performing expensive health screens on rodents in a conventional facility is questionable unless required for disease investigation. There is extensive research about the impact of pathogens on experimental parameters. A review of the type of experimental work being conducted in an animal facility and the common pathogens found in local rodent facilities, can assist in prioritizing the pathogens to be included in health-monitoring. Once the pathogen list is decided, the methodology chosen must take into account factors such as cage type, origin of animals, availability of dependable sentinels, and the value of individual rodents. Technological advances are changing the type of samples required for health monitoring and the number of international laboratories specializing in the health screening of rodents is improving access to health monitoring services. In conducting a cost benefit analysis, the value of utilizing some in-house health monitoring versus outsourcing all work to external laboratories needs to be considered. While the cost of health monitoring provides the boundaries, a good health monitoring programme is designed around the animal facility itself.


    Show Resources
    You May Also Like
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    JUN 17, 2020 1:30 PM PDT
    C.E. CREDITS
    JUN 17, 2020 1:30 PM PDT
    Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
    AUG 18, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    AUG 18, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: August 18, 2020 TIME: 10:00am PT Get deeper understanding of gene expression patterns by using assays that retain spatial organization at single cell resolution! Come learn about the n...
    JUN 09, 2020 10:00 AM PDT
    C.E. CREDITS
    JUN 09, 2020 10:00 AM PDT
    DATE: June 9, 2020 TIME: 10:00am PT, 1:00pm ET The presentation will first discuss sepsis as a disease and then explain the importance of performing diagnostic tests in the clinical labora...
    Loading Comments...
    Show Resources
    Attendees
    • See more