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JUN 17, 2020 7:30 AM PDT

Development of Luminex Based Serological Test for COVID-19 Diagnosis and Monitoring

Sponsored by: LUMINEX
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Postdoctoral Fellow at Rush University Medical Center in Chicago
    Biography
      Imad Tarhoni, MD, PhD is currently a Postdoctoral Fellow at Rush University Medical Center in Chicago, Illinois, where his main research goals center on developing diagnostic tests, including those for cancer and COVD-19 related diseases. His interest for science, has been an active one, where, after earning his medical degree from the University of Zawiya in Libya and serving as physician and faculty member in the department of clinical biochemistry, his passion for pursuing a physician-scientist career path compelled him to travel to the USA to seek further professional training. In 2012 through 2019, Imad earned his Master's and PhD degrees in the laboratory of Dr. Jeffrey A. Borgia at Rush University Medical Center, where his training focused on diagnostic test development and validation in Cancer biology. Imad is also an active member of the American Society of Clinical Pathology and the American Association for Clinical Chemistry with track record scientific contributions. His long term career goal is to pursue precision medicine advancement through formal board eligible pathology training.

    Abstract

    Coronavirus disease 2019 (Covid-19) is a global pandemic that has impacted the lives of the entire world’s population. Accurate and effective testing mechanisms to identify those with active infections or have convalesced is necessary to properly monitor and control this infectious agent. To this end, we have recently developed a serological method for assessment of an immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogen based on simultaneous evaluation of four viral antigens, including the Spike, Nucleocapsid, Membrane, and Envelope glycoproteins, and built on the Luminex immunobead platform. Validation studies against 1042 patients have provided test performance characteristics of 100% Sensitivity, 99.6% Specificity, and 99.62% overall accuracy, relative to PCR-based assignments. This quantitative method is highly effective in applications that include diagnosis of those with past infections (symptomatic or asymptomatic), epidemiological studies/ guidance for policy decisions, monitoring titers during vaccine trials, and rationalized donor selection for therapeutic ‘convalescent plasmapheresis’ strategies.

    Learning Objectives:

    1. To understand the best testing strategy to survey COVID-19 in population in order to constrain the disease and prepare for safe reopening

    2. To understand the advantage of multiplexing technology to improve testing accuracy and sensitivity


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