JUN 29, 2018 9:00 AM PDT

Diet and gene interactions in the control of central cell metabolism

Speaker
  • PhD student, Quadram Institute Bioscience/University of East Anglia
    Biography
      Sophie is a BBRSC funded PhD student studying the role of dietary compounds in the genetic control of cell metabolism at the Quadram Institute, UK. Aside from her research duties, Sophie is a keen science communicator. As city coordinator for the 'Pint of Science' outreach festival and chair/founder of the UEA Science Communication society, Sophie manages various public engagement initiates which she advertises through local TV/Radio and print media streams. By combining her scientific expertise with a fierce passion for adults' education and lifelong learning, Sophie hopes to integrate her research career with media production for mass education post-PhD.

    Abstract
    DATE: June 29, 2018
    TIME: 09:00AM PDT, 12:00PM EDT

    There is significant epidemiological evidence to suggest that the consumption of a high-broccoli diet is associated with a reduced risk of cancer and cardiovascular disease. Human intervention studies have shown that a broccoli-rich diet can reduce cholesterol levels and rebalance central cell metabolism. Our studies also show that the effect of diet is also influenced by the allelic status of a gene known as PAPOLG, an RNA poly(A) polymerase not previously associated metabolic homeostasis. Through the use of in vitro cell models, high throughput metabolomics and live cell energy phenotyping, the nutrigenetic relationship between PAPOLG and the broccoli-rich diet can be explored. In this webinar I will expand upon the link between broccoli bioactives and metabolic homeostasis, highlight the potential role of RNA turnover in metabolic control, and offer insights into the potential implications for the dietary prevention of disease.

    Learning Objectives:

    • To understand the role of broccoli-derived bioactives in metabolic regulation
    • To understand the role of RNA turnover in acute metabolic regulation
    • To explore the use of dietary compounds in the prevention of disease

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