SEP 30, 2019 08:00 AM PDT
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Discovery and Verification of eQTLs Associated with Lung Adenocarcinoma

Speakers
  • Former Director of the research unit "Genetic Epidemiology and Pharmacogenomics", Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
    Biography
      Tommaso A. Dragani is a former director of a cancer research group at the Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. He has over 30 years of experience in cancer research with an emphasis on genetic susceptibility to common cancer, in particular lung cancer. He has published 176 papers in peer-reviewed scientific journals in the field of chemical carcinogenesis and genetic epidemiology. His studies have helped to shed light on the mechanisms of chemical carcinogenesis and genetic predisposition to cancer, in animal models and in humans. He has experience in teaching, having taught courses to university students and specialized doctors, and in the training of students and doctoral students. In his current role Tommaso is responsible for the management of two research projects of which he is the principal investigator.
    • Senior Product Application Scientist
      Biography
        Harita Veereshlingam is a Senior Product Application Scientist in the Genetic Sciences Division at Thermo Fisher Scientific. She has over 10 years of experience in product development with an emphasis on real time PCR assays for gene expression and miRNA analysis. In her current role, Harita is responsible for product portfolio growth through the development of novel applications, customer collaborations, technical notes, and webinars. She lives by and is a strong proponent of sustainable living. She has a PhD in Molecular Biology from the University of North Texas.

      Abstract:
      DATE:  September 30, 2019
      TIME:   8:00am PDT, 11:00am EDT, 5pm CEST
       
       
      Expression quantitative trait loci (eQTLs) are SNPs that have an influence on expression levels of genes, and the identification and characterization of eQTLs involves the overlap of genomic and transcriptomic analyses. Analysis of eQTLs provides a means for understanding the link between genetic variants and altered gene expression, and could potentially provide new insights connecting GWAS results to molecular mechanisms. eQTLs have become extremely important in understanding mechanisms of disease progression and are gaining importance as biomarkers in diseases.
       
      Lung adenocarcinoma accounts for more than 40% of all lung cancers, and heritability is considered to play a significant role in the development of this disease, among other factors. Although previous GWAS have identified several lung cancer susceptibility loci, the functionality of most of these loci still remains unexplained. Studying eQTLs associated with lung adenocarcinoma could help us understand the function of these loci and provide further insights into the molecular mechanism of this disease.
       
      Thermo Fisher Scientific’s microarray solutions enable genome-wide and transcriptome-wide analysis with simple workflows and data analyses packages. In this study we demonstrate a streamlined workflow using the Applied Biosystems Axiom Precision Medicine Research Array (PMRA; for genotyping) and the Clariom D Assay (for gene expression) to discover/screen eQTLs associated with lung adenocarcinoma. We also show how these eQTLs can be verified using TaqMan Genotyping and Gene Expression Assays for real-time PCR.
       
      Learning Objectives:
      • Importance of studying eQTLs in diseases
      • Affymetrix microarrays to discover eQTLs 
      • TaqMan QPCR assays to verify eQTLs
       
       
       
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