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Disease modelling with human pluripotent stem cells: general principles and specific applications to obesity

Speaker

Abstract

The capacity to generate disease-relevant cell populations from human pluripotent stem cells has tremendous potential for shedding light on human disease mechanisms. I will discuss basic principles of in vitro disease modelling, including the generation of isogenic models with CRISPR/Cas9, the issue of recurrent culture-acquired mutations and how to assess stem cell genomic integrity, and cell type maturity and phenotyping strategies. To frame these issues, I will discuss my research group's interest in obesity, which is largely a disease of excess food intake, which is in turn regulated by neurons in the hypothalamus. We use human stem cell-derived hypothalamic neurons to gain insight into the environmental and genetic factors that alter neuron function.


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Disease modelling with human pluripotent stem cells: general principles and specific applications to obesity


Specialty

Neuroendocrinology

Cognitive Neuroscience

3D Simulation

Stem Cells

Neuroscience

Organ-On-A-Chip

Neuroradiology

Geography

North America50%

Asia50%

Registration Source

Website Visitors100%

Job Title

Student50%

Post Doc50%

Organization

Veterinary School50%

Academic Institution50%


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