MAR 20, 2014 2:00 PM PDT

Disinhibition Drives Rapid Movement and Associative Motor Memory Formation in the Cerebellum

Presented at: Neuroscience
Speaker
  • Investigator & Co-Director of the Neurotherapeutics IWI, Lundquist Institute (Formerly "LA BioMed"); Assistant Professor, David Geffen School of Medicine at UCLA Department of Neurology
    BIOGRAPHY

Abstract

Motor coordination relies on accurate predictions that specify how the body should move in particular sensorimotor contexts. Although such predictions are thought to be stored as associative motor memories in the cerebellum, the circuit mechanisms by which they form and are acted upon remain unclear. Correlates of such memories, typically reductions in the firing rate of Purkinje neurons in advance of a learned movement, have been observed in the firing patterns of cerebellar Purkinje neurons. Given that Purkinje neurons powerfully inhibit deep cerebellar nuclei neurons, and that some deep cerebellar nuclei neurons project directly to motor nuclei like the red nucleus, pauses in spontaneous Purkinje neuron firing have the potential to drive motor output. However, it is unclear whether reductions in Purkinje neuron firing alone are sufficient to drive movement, and if so whether their ability to drive movement depends upon prior learning. To examine these questions we have utilized an approach to selectively manipulate Purkinje neuron firing activity in an awake, behaving animal while simultaneously monitoring cellular activity or motor movement. Together, the results I will present indicate movements driven by Purkinje neuron pauses are influenced by whether or not learning has occurred, and support the hypothesis that during learning Purkinje neuron activity instructs memory-related changes in the deep cerebellar nucleus.


Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
FEB 24, 2021 10:00 AM PST
C.E. CREDITS
FEB 24, 2021 10:00 AM PST
DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
MAR 16, 2021 10:00 AM PDT
C.E. CREDITS
MAR 16, 2021 10:00 AM PDT
Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
APR 21, 2021 10:00 AM PDT
C.E. CREDITS
APR 21, 2021 10:00 AM PDT
Date: April 21, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Serological testing for SARS-CoV-2 has been steadily adopted into clinical practice over the course of this pandemic. In this webinar,...
MAR 20, 2014 2:00 PM PDT

Disinhibition Drives Rapid Movement and Associative Motor Memory Formation in the Cerebellum

Presented at: Neuroscience

No demographic data is available yet for this event.


Show Resources
Loading Comments...
Show Resources