AUG 22, 2013 01:00 PM PDT

Dominant regulation of gene expression by microRNAs

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  • Principle Investigator, Genome Laboratory, Tel Aviv University
      Dr. Noam Shomron heads a research team which focuses on the analysis of genomic sequences and gene expression aimed at understanding human diseases. Dr Shomron trained at Massachusetts Institute of Technology (MIT, Cambridge, MA, USA) where he combined high-throughput methods with computational analysis. Dr Shomron joined Tel Aviv University's Medical School in October 2008. Dr Shomron's is highly skilled in deep (next generation) sequencing technologies, in addition to parsing and processing the sequencing output. His strength in the genomic world stems from his extensive experience and knowledge using state-of-the-art methods both experimentally and computationally. Dr Shomron's overall interest and goals lie within seeking a better understanding of the mechanisms leading to disease development. His team seeks innovative solutions to generate a significant impact through translating ideas into clinical reality. Dr Shomron is also the Director of Rare Genomics Institute's Israel branch; co-founder and Scientific Director of the Functional Genomics Laboratory at Tel Aviv University; Editor-in-Chief of ‘Genetics Research' (published by Cambridge University Press); Editor of ‘Deep Sequencing Data Analysis' (a ‘Methods in Molecular Biology' book series published by Springer/Humana Press), Academic Director of BioAbroad.

    MicroRNAs are short non-coding cellular regulators of gene expression. Each microRNA controls the expression of a large set of genes, and microRNAs collectively, may regulate more than half of human genes. In the laboratory, our team focuses on understanding the function of microRNAs in health and during disease. We map their expression in developing cancer cells and in various brain disorders. We predict direct gene targets of these microRNAs sets and then pinpoint the cellular pathways affected. I will present our recent findings in the field and discuss its potential implications for prognosis and diagnosis. Overall our team pursues research that aims to deepen our understanding on the development of diseases in order to generate a significant impact through translating ideas into clinical reality.

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