MAY 31, 2022 6:00 AM PDT

EAD: Structural elucidation of difficult to classify metabolites using orthogonal fragmentation modes

Sponsored by: SCIEX
Speaker

Abstract
Date:  May 31, 2022
Time: 6:00am (PDT),  9:00am (EDT), 3:00pm (CEST)
 
This webinar will introduce why deep structural elucidation of drug candidate metabolism is a requisite part of early- to late-stage drug discovery. Early studies are used to determine if a drug candidate is prone to metabolic breakdown or oxidation/conjugation. This presentation showcases how both electron activated dissociation (EAD) and collision induced fragmentation (CID) bring new levels of interpretive power to the routine, but often challenging, process of metabolite identification. EAD utilizing a high-energy, electron-based fragmentation mechanism produces alternative fragments compared to CID. EAD generates a richer, more in depth fragmentation pattern than CID and can generate site specific spectral peaks for labile fragments that would otherwise be lost.
 
Learning Objectives
  • EAD is a reagent free, tunable technique that is applicable to a broad range of molecule types and tunable to small singly charged and multiply charged molecules
  • EAD provides orthogonal, complimentary fragmentation to CID, allowing more thorough, confident metabolic structure elucidation than with CID alone
  • The Zeno trap provides enhanced sensitivity in MS/MS modes, allowing characterization of low level metabolites for both CID and EAD fragmentation
 
 
Webinars will be available for unlimited on-demand viewing after live event.
 

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