OCT 16, 2013 11:00 AM PDT

Embracing Complexity: Drosophila as a Tool to Develop Cancer Therapeutics

C.E. Credits: CE
Speaker
  • Associate Dean of the Graduate School of Biological Sciences and Professor of Oncological Sciences, Icahn School of Medicine at Mount Sinai
    BIOGRAPHY

Abstract

Cancer and diabetes are complex diseases that have proven difficult to treat in the clinics. Until recently, most efforts have focused on hitting individual therapeutic targets cleanly. Unfortunately, success rates in clinical trials have been low: in the case of cancer, success rates for individual drugs have commonly been in single digits. This suggests that our models are poorly predictive of useful therapeutics. One issue is disease complexity. Another is the importance of modeling disease in the context of the whole animal. I will discuss our efforts using Drosophila to build complex cancer and diabetes models in the context of the whole animal. We utilize genomic sequencing data to create multi-hit fly models, either of disease populations or of individual patients. We then use automated systems to screen libraries for useful drugs. In addition, I will describe how we combine Drosophila genetics plus medicinal chemistry to create new generation candidate therapeutics.


Show Resources
You May Also Like
FEB 15, 2023 7:00 AM PST
FEB 15, 2023 7:00 AM PST
Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
NOV 16, 2022 7:00 PM PST
C.E. CREDITS
NOV 16, 2022 7:00 PM PST
Date: November 16, 2022 Time: 2:00pm (AEST) Date: November 17, 2022 7:00pm (PST), 10:00pm (EST), 4:00am (CET) The growth in FDA-approved cell and gene therapy products for the treatment of d...
AUG 16, 2022 11:00 AM PDT
AUG 16, 2022 11:00 AM PDT
Date: August 16, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) Understanding genomic variation in the context of cancer is paramount to identifying disease drivers and informing pers...
OCT 11, 2022 8:00 AM PDT
C.E. CREDITS
OCT 11, 2022 8:00 AM PDT
Date: October 11, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Multiomic profiling of cell populations at single-cell resolution is revolutionizing scientists’ understanding o...
OCT 13, 2022 9:00 AM +08
OCT 13, 2022 9:00 AM +08
First Broadcast: Date: October 12, 2022 Time: 8:00am PDT, 11:00am EDT Second Broadcast: Date: October 12, 2022 Time: 9:00am SGT The new Embedded CryoSPARC Live, now fully integrated with t...
OCT 16, 2013 11:00 AM PDT

Embracing Complexity: Drosophila as a Tool to Develop Cancer Therapeutics

C.E. Credits: CE


Show Resources
Loading Comments...
Show Resources