SEP 16, 2015 2:00 PM PDT

Enabling the Best Structure-Based Design Engine:a Human Expert

Speakers
  • Director of Computational Chemistry & Cheminformatics Genentech
    Biography
      Jeff Blaney is the at Genentech. Prior to Genentech, Dr. Blaney held executive positions at SGX Pharmaceuticals, Metaphorics, DuPont Pharmaceuticals, and Chiron… just to name a few. Dr. Blaney obtained his Ph.D. in Pharmaceutical Chemistry from the University of California, San Francisco. Dr. Blaney has many years of experience in industrial drug discovery research, focusing on structure-based design, high-throughput docking, combinatorial library design, and chemical informatics.

    Abstract:
    Structure-based drug discovery requires expert designers, aided by software that integrates 3D structure visualization and molecular editing with multivariate experimentaland calculated properties. Structural biology now provides excellent support for most small drug discovery targets and frequently delivers 10s to 100s of co-crystal structures, which must be aligned, annotated, selectively displayed, edited to design new analogs, and tightly integrated with project data. I'll describe our approaches to enable Structure-Based Design.

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