Professor, Chair of Stem Cell Sciences, Program Leader, Stem Cells Australia, The University of Melbourne, Walter and Eliza Hall Institute of Medical Research, Florey Neuroscience and Mental
Using human pluripotent stem cells as a screening platform, we have identified a novel cell surface maker that identifies foregut endoderm progenitors in pancreas and liver. We have shown that cells of the biliary reaction, a regenerative response to liver damage, premalignant and pancreatic ductal adenocarcinoma cells, and the columnar epithelium of Barrett’s Oesophagus, a preneoplastic precursor of oesophageal carcinoma, all express this antigen on their surface. The antigen is expressed in liver and pancreas during development, and is also found in the serum of patients with pancreatic or liver cancer. Cell surface antigens expressed on fetal stem or progenitors cells provide biomarkers of tissue regenerative processes, and can be used to monitor progression neoplasia if repair processes fail to resolve the underlying pathology.
Date: September 22, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarke...
Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
Date: November 16, 2022 Time: 2:00pm (AEST) Date: November 17, 2022 7:00pm (PST), 10:00pm (EST), 4:00am (CET) The growth in FDA-approved cell and gene therapy products for the treatment of d...
Date: November 09, 2022 Time: 8:00am (PST), 11:00am (EST), 5:00pm (CET) The field of cell and gene therapy is rapidly growing. In particular, the use of lentiviruses in CAR-T applications is...
Date: August 16, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) Understanding genomic variation in the context of cancer is paramount to identifying disease drivers and informing pers...
DATE: August 17, 2022 TIME: 10:00am PDT, 1:00pm EDT Detection and/or amplification of target DNA sequences by polymerase chain reaction (PCR) is a prevalent method in molecular biology. PCR...
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