Compassion fatigue, or the state of chronic stress for those caring for people or animals in distress, can affect anyone working in the lab animal sciences. This can even affect employees who do not work directly with the animals on a daily basis. Working in this field can make it harder for people to get support from their external support system, such as family or friends, since many of them are unfamiliar with the challenges in the field. This makes it imperative that the workplace fills the gap and provides additional support. An enrichment program that has a foundation of engagement for everyone in the animal care and use program is an avenue to help address compassion fatigue. By combating compassion fatigue the institution can provide a healthier workplace for their staff and animals.