FEB 21, 2024 6:00 AM PST

Enhancing Synthesis Workflows Through Computer-Assisted Retrosynthesis with Live Q&A

Sponsored by: Merck
Speaker

Abstract

Advancements in the field of drug discovery and chemical development have necessitated the integration of computer-assisted technologies to expedite processes, uncover efficiencies, and foster innovation in synthesis workflows. SYNTHIA™ retrosynthesis software has emerged as a powerful tool, utilizing sophisticated algorithms, advanced chemical logic, and an expert-coded chemistry rule database to efficiently identify pathways for known and novel synthetic targets. By applying user-guided customizations to search parameters, tailored results can be obtained to meet specific project requirements. The seamless customizability of SYNTHIA™ facilitates its integration into diverse technology workflows. Although significant progress has been made, synthetic chemistry remains a highly complex and time-consuming field. The synthesis of novel molecules with unique properties is crucial for drug discovery but often poses challenges and causes bottlenecks in the overall process. To address this issue, the application of customized search parameters within SYNTHIA™ enables the efficient planning of routes to target molecules. This optimized approach eliminates the need for extensive time spent on manual route planning, searching for appropriate starting materials, and executing bench experiments. Consequently, the drug discovery process is accelerated, enabling researchers to focus on crucial aspects of molecule development and property optimization.


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