FEB 08, 2018 09:00 AM PST

Evaluation of the Neutrophil: Lymphocyte Ratio as an Indicator of Chronic Distress in the Laboratory Rodent

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  • Director, Laboratory Animal Resource Center, Indiana University
      Dr. Hickman graduated with her DVM from the University of Illinois at Urbana-Champaign. She is a Diplomate of the American College of Laboratory Animal Medicine and the American College of Animal Welfare. She currently is the Director for the Laboratory Animal Resource Center at the School of Medicine of Indiana University, Indianapolis, IN. She previously served as the Chief of Veterinary Services for the VA Medical Center in Portland, OR. She maintains an active research laboratory that uses a combination of physiology and behavior to assess animal well-being with a goal to improve the care of animals used in research. Current work has included development of novel assessment tools, exploration of how cage environment can be manipulated to improve well-being, and strategies to improve the process of euthanasia.


    Assessment of how changes in husbandry affect an animal can be challenging as most common methods of assessment, such as corticosterone levels, are more reliable for assessment of acute stress. Our laboratory has evaluated and characterized the neutrophil: lymphocyte ratio as a more sensitive tool for assessment of chronic distress. In this talk, we will review the effectiveness of the neutorphil: lymphocyte ratio. 

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