Expanding the Cell Painting Tool Kit: Optimizing Imaging Across Diverse and Challenging Cell Lines

Cell painting has established itself as a powerful tool for high content imaging, able to generate vast quantities of data in response to chemical perturbations. Over the past decade, cell painting experiments have traditionally focused on a narrow range of well-studied cell lines against a range of tool compounds. However, as the field evolves there is a growing interest in extending the utility of this powerful technique to a broader array of cell types, including previously untested cell lines and primary cells. This webinar will explore the challenges and opportunities associated with cell painting in these largely untested systems, looking at different cell lines and their utility in studying phenotypic changes in response to compounds. By assessing different cellular lineages, it is possible to show different phenotypic responses to the same treatment, highlighting a potentially important predictive tool in the future of drug discovery.

 

Learning Objectives