NOV 02, 2020 8:00 AM PST

The Expanding Role of Next-Generation DNA Sequencing (NGS) in PJI Diagnosis and Clinical Microbiology - Part II

Sponsored by: MicroGenDX
C.E. Credits: P.A.C.E. CE Florida CE
Speakers
  • James Edwards Professor of Orthopedic Surgery-Sidney Kimmel Medical College, Thomas Jefferson University Director of Clinical Research, Rothman Institute, Thomas Jefferson University Hospital
    Biography

      Dr. Parvizi is a board certified orthopaedic surgeon and has been at the Rothman Institute since 2003. He specializes in the management of young patients with hip disorders such as dysplasia and femoroacetabular impingement. He has performed over 1000 femoroacetabular osteoplasty procedures, 300 pelvic and femoral osteotomies, and over 5000 hip replacements in young adults and continues to lead the clinical research team at the Rothman Orthopaedic Institute. Dr. Parvizi is a native of Azerbaijan, Iran and lived there until the age of 16. He completed his medical school education in the United Kingdom. Following graduation from medical school he spent four years in surgical training that included cardiothoracic surgery. Dr. Parvizi then traveled to the United States to spend two years at the Mayo Clinic to conduct research in identifying methods to regenerate cartilage and bone. After obtaining a Masters degree in molecular biology from the Mayo Clinic, Dr. Parvizi was offered a residency in orthopedic surgery at the Mayo Clinic. He completed his residency in orthopedic surgery at the Mayo Clinic and traveled to Switzerland to do a fellowship in the management of hip disorders in young adults. He spent time with Professor Ganz at the Inselspital, Berne in 2002. After completion of his fellowship, he joined the Rothman Orthopaedic Institute. His personal area of interest in research and clinical practice includes prevention and diagnosis of joint infection, joint preservation in adults, and prevention of thromboembolism following orthopedic procedures. He has published over 700 scientific articles and has written 18 text books in related subjects including books on THE HIP and on THE KNEE. He has received numerous awards from societies and has received funding for his research from the National Institute of Health, Department of Defense, Orthopedic Research and Education Foundation, Musculoskeletal Transplant Foundation, Arthritis Foundation and numerous other funding bodies. Dr. Parvizi travels extensively across the globe to give lectures related to his area of expertise and has been given the honorary membership of numerous societies around the world. He has served as the president of Musculoskeletal Infection Society (2013), Eastern Orthopedic Association (2018) and holds position the board of numerous organizations and societies.

    • Professor of Pathology and Laboratory Medicine, University of Louisville - Medical Director of the Clinical Microbiology & Molecular Diagnostics Laboratory, University of Louisville Hospital
      Biography

        Dr. Snyder is currently the Director of Microbiology and Infectious Disease Molecular Diagnostics at the University of Louisville Hospital, Louisville, KY. He holds the academic title of Professor in the Department of Pathology and Laboratory Medicine. He is board certified in Medical Microbiology and Public Health by the American Academy of Microbiology and was elected to Fellowship in the Academy in 1989.

        Prior to joining the University of Louisville School of Medicine, Dr. Snyder served as the Director of Microbiology at the Norton-Kosair Children’s Hospital (1977-1986) and the Veteran’s Administration Medical Center in Louisville (1973-1977).

        Dr. Snyder has over 35 years of experience in the field of clinical microbiology and has authored or co-authored over 70 papers in the peer reviewed literature, has 10 book chapters to his credit, and has presented numerous research posters in addition to being a frequent invited speaker. He holds professional memberships in the American Society for Microbiology, South Central Association for Clinical Microbiology, and the Infectious Disease Society of America. He currently serves on several editorial boards including the Journal of Clinical Microbiology, Journal of Surgical Infections, and Diagnostic Microbiology and Infectious Diseases. 

        Dr. Snyder led the development of the ASM Sentinel Level Laboratory Guidelines for BioThreat Agents. His most recent contribution was as the Senior Author of a Systematic Review and Meta Analysis for the Laboratory Detection of Clostrioides difficile. Dr. Snyder served 43 years in the Army Reserves, and commanded the Medical Task Force in Iraq in 2011; and retired, at the rank of Colonel, in September 2012.


      Abstract

      Date:  November 2, 2020

      Time: 8:00am PDT

       

      Timely and accurate detection of an infective organism(s) impacts the treatment course and potentially patient outcomes. Although traditional culture has served as the “gold standard” for the recovery and isolation of potential pathogens, NGS, a culture independent genomic technology, has become attractive to undertake coincidently for the genotypic detection of potential pathogens.  The limitations inherent in traditional microbiological culture techniques—including how biofilm, viable but non-culturable bacteria, and persister cells hinder diagnosis and treatment of these infections—were discussed in detail in Part 1 of this webinar series. Watch On-Demand

      NGS has played an important role in the detection of potential microbial pathogens in patients with periprosthetic joint infection (PJI), when infection exists in the form a biofilm and traditional culture fails to isolate the etiological agent in up to 50% of cases. Recent studies have shown that NGS can determine the type of pathogen(s) causing PJI in 90% of the cases when culture was negative. Further, studies have shown that NGS is also extremely useful in urosepsis, neurological infections, and many other fields. 

      NGS provides more comprehensive information about the presence of microbial population, results are usually available in <24 hours in most cases and is cost effective. There is ample evidence to support the use of NGS in management of patients with infection.

      In this webinar, we will cover:


      •    Surgeon’s perspective: Dr Javad Parvizi, a recognized expert in the field of orthopedic infections, will provide his perspective on the use of NGS in orthopedic infections. He will present the data generated over the last four years in using NGS in orthopedics at the Rothman Orthopaedic Institute (Jefferson University Hospitals) and findings of the landmark multi-center study that includes centers such as Cleveland Clinic, Hospital for Special Surgery and so on. 
      •    Microbiologist’s perspective: Dr James Snyder, Professor of Pathology and Medical Director of the Clinical Microbiology Laboratory of the University of Louisville Hospital, will talk about their experience of incorporating NGS testing into their microbiology laboratory workflow and lessons learned.  
       

       

      Webinars will be available for unlimited on-demand viewing after live event.

       

      LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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