MAY 11, 2017 10:30 AM PDT

Functional Characterization of Gene Regulatory Elements

C.E. Credits: CEU
Speaker
  • Professor, Department of Bioengineering and Therapeutic Sciences, Institute for Human Genetics, UCSF
    Biography
      Dr. Nadav Ahituv is a Professor in the Department of Bioengineering and Therapeutic Sciences and the Institute for Human Genetics at the University of California, San Francisco. He received his PhD in human genetics from Tel-Aviv University working on hereditary hearing loss. He then did his postdoc, specializing in functional genomics, in the Lawrence Berkeley National Laboratory and the DOE Joint Genome Institute. His current work is focused on identifying gene regulatory elements and linking nucleotide variation within them to various phenotypes including morphological differences between species, drug response and human disease. In addition, his lab is developing massively parallel reporter assays (MPRAs) that allow for high-throughput functional characterization of gene regulatory elements.

    Abstract

    Nucleotide variation in gene regulatory elements is a major cause of human disease. Despite continual progress in the cataloging of these elements, little is known about the code and grammatical rules that govern their function. Deciphering the code and their grammatical rules will enable high-resolution mapping of regulatory elements, accurate interpretation of nucleotide variation within them and the design of sequences that can deliver molecules for therapeutic purposes. To this end, we are using massively parallel reporter assays (MPRAs) to simultaneously test the activity of thousands of gene regulatory elements in parallel. By designing MPRAs to learn regulatory grammar or to carry out saturation mutagenesis of every possible nucleotide change in disease causing gene regulatory elements, we are increasing our understanding of the phenotypic consequences of gene regulatory mutations. 


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    MAY 11, 2017 10:30 AM PDT

    Functional Characterization of Gene Regulatory Elements

    C.E. Credits: CEU

    Specialty

    Gene Expression

    Flow Cytometry

    Drug Discovery

    Cell Culture

    Big Data

    Biotechnology

    Tumor

    Antibodies

    Cancer

    Immuno-Oncology

    Cell

    Dna Sequencing

    Clinical Diagnostics

    Mass Cytometry

    Cancer Diagnostics

    Geography

    North America50%

    Europe50%

    Registration Source

    Website Visitors100%

    Job Title

    Student100%

    Organization

    Academic Institution100%


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