MAR 15, 2017 1:30 PM PDT

New generation open source miniaturized microscopes for network dynamic imaging in freely moving mice

Presented at: Neuroscience 2017
Speaker

Abstract

Miniaturized microscopes in combination with genetically encoded calcium indicators now allow recordings of activity from hundreds of neurons simultaneously in freely moving animals. We are building new generation open source miniaturized microscopes with expanded capabilities.  First, we have built and wireless miniaturized microscopes allow unfettered recordings for over 15 minutes.  These microscopes will allow recordings from a number of behaviors that have been thus far been impossible. For example, the microscopes will allow recordings from mice behaving in very large naturalistic arenas or complex tunnel complexes.  Second, we are building microscopes with combined optogenetics and calcium imaging capabilities, so that the activity of neurons can be manipulated while recording from the same group of cells.  Third, we are developing microscopes with combined electrophysiology and imaging capabilities to correlate imaging findings with electrophysiological signatures.  Finally, our first generation microscopes have already been released into our open-source wiki (miniscope.org) and over 150 labs are currently building and using the microscopes.  As the new generation microscopes are tested and optimized they will also be released to the community.


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MAR 15, 2017 1:30 PM PDT

New generation open source miniaturized microscopes for network dynamic imaging in freely moving mice

Presented at: Neuroscience 2017


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