AUG 22, 2013 05:00 PM PDT

Genomic Profiles of Asian Endemic Cancers

  • Professor, Cancer & Stem Cell Biology Pgm, Duke-NUS Graduate Medical School Singapore, Sr. Group Leader, Genome Institute of Singapore, Program Leader, Genomic Oncology, Cancer Science In
      Dr. Patrick Tan holds a joint appointment as a Professor at the Duke-NUS Graduate Medical School and Senior Group Leader at the Genome Institute of Singapore. He is also Senior Principal Investigator at the Cancer Science Institute of Singapore, National University of Singapore and Research Associate Professor in the Institute of Genome Sciences and Policy at Duke University, USA. His research focuses on the application of genomics to cancer and infectious disease. He received his B.A. (summa cum laude) from Harvard University and MD PhD degree from Stanford University, where he received the Charles Yanofsky prize for Most Outstanding Graduate Thesis in Physics, Biology or Chemistry. Other honors include the President's Scholarship, Loke Cheng Kim foundation scholarship, Young Scientist Award (A-STAR), Singapore Youth Award (twice), Singhealth Investigator Excellence Award, Han-Mo Koo Memorial Lectureship (Van Andel Research Institute, USA) and Swee Liew Wadsworth Lectureship (NUS). Recently, he received the Chen New Investigator Award from the Human Genome Organization (HUGO), and was elected to the American Society for Clinical Investigation (ASCI). He is a member of the Bioethics Advisory Committee (BAC), a national body that provides advice to the Singapore government on ethical issues related to biomedical research.

    Malignancies caused by so-called Type I chemical and biological carcinogens provide important opportunities studying early events in cancer development, providing essential information for developing future cancer prevention strategies. In Asia, several highly lethal cancers are known to be caused by pathogens, such as stomach cancers (H. pylori), bile duct cancers (liver flukes), and certain lymphoma subtypes (Epstein-Barr Virus). For many of these conditions, treatment options are still highly limited. In this talk, I will describe how genomic analysis of infection-related Asian cancers can provide insights into cellular processes disrupted by these pathogens, and how such data can be used to identify new therapeutic targets.

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