MAY 18, 2021 7:00 AM PDT
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Hitting the Achilles' Heel of Cancers with Confidence - Robust Validation of Neoantigens

Sponsored by: Agilent
Speaker
  • Founder and CEO, Complete Omics Inc.
    Biography

      Dr. Wang is the founder and CEO of Complete Omics Inc. He graduated from Johns Hopkins University with a PhD, supervised by Dr. Bert Vogelstein at the School of Medicine, and an MHS in Biostatistics, supervised by Dr. Rafael Irizarry at the Bloomberg School of Public Health. Before coming to the US, he obtained his BS and MS in Molecular Biology from Nankai University and trained with Dr. Tianhui Zhu, the Founding Dean of Nankai University School of Medicine. Dr. Wang is also currently pursuing an Executive MBA from The Wharton School of the University of Pennsylvania and will obtain his degree in 2023. During the past 15 years, Dr. Wang's research has focused on clinical proteomics and clinical genomics. In 2007, Dr. Wang joined Dr. Bert Vogelstein's lab at JHU as a PhD student and initiated a program for clinical proteomics. In 2010, Dr. Wang developed the world's first mutant protein detection and quantification platform, “MT-SRM”, a pipeline capable of quantifying protein copy numbers in a single human cell with mass spectrometry. Next, Dr. Wang developed the first scalable proteomics biomarker discovery and validation platform, “SAFE-SRM”, which launched the use of mass spectrometry-based proteomics into the clinical setting. In 2019, he invented the pipeline “MANA-SRM” and “Valid-NEO” for direct detection and quantification of neoantigens from cells and minute quantities of human tumor tissue, which has paved the way for a new generation of personalized cancer therapeutics. Recently, he developed a comprehensive clinical proteomics molecular diagnostics platform, “Complete360”, which enables multi-omics-based quantification of a large number of biomarkers in human body fluid samples. He also invented and patented a genomics-based platform, “DEEPER-Seq”, the world's only barcoded single-stranded library and dual RNA probe-based targeted sequencing platform for ultra-rare mutation calling with Next Generation Sequencing (NGS). Dr. Wang's research has been featured in major media outlets, including Genomeweb, Newswire, ScienceDaily, and numerous major media from China (screenshots provided at the end of this document) as well as traditional high impact peer-reviewed journals. Through Complete Omics Inc., Dr. Wang is working to break the boundaries between different fields in medicine and the life sciences, and to comprehensively leverage the features of omics technologies to achieve improved personalized disease management and precision medicine.


    Abstract
    Date:  May 18, 2021
    Time: 7:00am PDT, 10:00am EDT
     
    Proteins encoded by mutant genes in cancers can be processed and presented on tumor cell surface by human leukocyte antigen (HLA) molecules, and such mutant peptides are called Neoantigens. Neoantigens are naturally existing tumor markers. To identify the exact sequence of a neoantigen with high confidence is the key to the success of many cancer immunotherapeutics. In this presentation, we will discuss advancements and difficulties of prediction-dependent and prediction-independent neoantigen identification strategies. We will review the latest development of technologies for neoantigen identification and introduce our unique neoantigen detection and quantification pipeline based on a triple quadrupole mass spectrometer.
     
     
    Learning Objectives:
    • Gain familiarity of the advancements and difficulties of prediction-dependent and prediction-independent neoantigen identification strategies.
    • Understand the latest development of technologies for neoantigen identification
     
     
    For Research Use Only. Not for use in diagnostic procedures.
     
     
    Webinars will be available for unlimited on-demand viewing after live event.

     

     


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