Immune-derived extracellular traps in COVID-19 and other infections

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Research Fellow, Semmelweis University, Academic Trainee, Columbia University Mailman School of Public Health
    Biography

      Imre Varju is a Fulbright Scholar in medical science and a Health Communication Specialist with nearly 10 years of experience working with Neutrophil Extracellular Traps, with a special focus on their contribution to immunothrombosis. He obtained his MD and PhD at Semmelweis University, Hungary, completed postdoctoral trainings at the Hungarian Academy of Sciences, the National Institute for Biological Standards for Control, UK and at Harvard Medical School, and obtained his MPH at Columbia University. On top, he has been working as a Health Education Strategist at FCB Health New York.  


    Abstract

    As a response to various inflammatory stimuli, neutrophils and macrophages expel a mixture of their nuclear and granular elements in the form of extracellular traps (ETs). These web-like substances represent an evolutionarily conserved defense mechanism across humans, animals and even plants. ETs are composed of DNA, histones, and granular enzymes, and are capable of the entrapment of invading pathogens. Besides their protective function, ETs have been detected in a variety of pathological scenarios (from infections and autoimmune conditions to thrombosis) with detrimental effects, therefore they have been often referred to as ‘double-edged swords of immunity’. Most recently, neutrophil ETs have been identified as major contributors to the widespread immune-thrombosis in COVID-19 induced acute respiratory distress syndrome.

    Learning Objectives:

    1. Understand the basic types of ETs and the route of their formation

    2. Name three pathological conditions where ETs play a role

    3. Outline the suspected steps of ET contribution to (COVID-19 triggered) thrombosis


    Show Resources
    You May Also Like
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    DEC 02, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    JUL 22, 2020 10:00 AM PDT
    C.E. CREDITS
    JUL 22, 2020 10:00 AM PDT
    DATE: July 23, 2020 TIME: 10:00 am PDT The SARS-CoV-2 pandemic has taken a toll on many sectors of the medical community. As the pandemic took a grip on the laboratory, the need for diagnost...
    JUN 09, 2020 10:00 AM PDT
    C.E. CREDITS
    JUN 09, 2020 10:00 AM PDT
    DATE: June 9, 2020 TIME: 10:00am PT, 1:00pm ET The presentation will first discuss sepsis as a disease and then explain the importance of performing diagnostic tests in the clinical labora...
    AUG 25, 2020 8:00 AM PDT
    C.E. CREDITS
    AUG 25, 2020 8:00 AM PDT
    DATE: August 25, 2020 TIME: 8:00am PDT, 10:00am CDT, 11:00am EDT Recombinant lentivirus (LV) and adeno-associated virus (AAV) are critical components of cell and gene therapies, which show g...
    Loading Comments...
    Show Resources