Immunotherapy in Prostate and Renal Cell Carcinoma: Panoply of Futuristic Therapies

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Assistant Professor, Division of Medical Oncology, Huntsman Cancer Institute
    Biography

      Benjamin Maughan MD, PharmD is an Assistant Professor in the Division of Medical Oncology at Huntsman Cancer Institute specializing in genitourinary malignancies. Dr. Maughan completed his PharmD, cum laude, from Idaho State University in 2004, then completed an oncology pharmacy residency at Mountain States Tumor Institute in 2005. Dr. Maughan earned his MD, cum laude, from the University of Kentucky, College of Medicine in 2010. He finished his Internal Medicine residency training with the University of Utah in 2013 and subsequently completed his medical oncology fellowship at Johns Hopkins in 2016. He has been awarded the Huntsman Cancer Institute Translational Scholar Award in 2019, and was selected for the 2019 SWOG Young Investigator Training Course. Dr. Maughan has clinical and research interests in all genitourinary oncology, with a particular focus on the development of novel therapeutics and in identification of predictive biomarkers. During fellowship he studied predictive biomarkers in metastatic prostate cancer, specifically the role of truncated androgen receptors (AR-V7 expression) and loss of tumor suppressors (PTEN and Rb). More recently he is studying predictive biomarkers to immune therapy combinations in kidney, bladder and prostate cancers. He is exploring novel immune therapy combinations including checkpoint inhibitors combined with radiation therapy (radium-223), oncolytic viruses (MVA-brachyury) and targeted therapies (such as cabozantinib).


    Abstract

    Immune therapy approaches are being used in many different solid cancers today including clear cell renal carcinoma (mccRCC) and metastatic prostate adenocarcinoma. Over the past few years immune therapy has moved from later stage therapy in mccRCC to first line therapy. Additionally, combination therapy appears to be more effective than single-agent immune therapy in this disease setting. This presentation will compare the combination first-line therapies for mccRCC. Also we will discuss the current role for immune therapy in mPC and the ideal patient to treat with immune therapy. Finally we will discuss possible future combination immune therapies for mPC.

    Learning Objectives:

    1. Understand the optimal first-line therapies for patients with metastatic clear cell renal carcinoma

    2. Understand the impact of cancer vaccines in the treatment of metastatic testosterone suppression resistant prostate cancer (mCRPC)

    3. Define the optimal patient likely to benefit from Provenge


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