JUL 16, 2020 10:00 AM PDT

Implications of Rapid IDH1/IDH2 Testing for Liquid and Solid Tumors

Speaker
  • Clinical Development - Molecular Pathology lab at HUP
    Biography
      Sarah Herlihy, Ph.D. received her doctoral degree from Texas A&M University in 2014. She completed her post-doctoral studies at The Wistar Institute in Philadelphia before joining the Division of Precision and Computational Diagnostics at the Hospital of the University of Pennsylvania (HUP). Sarah has over 10 years of experience in academic and clinical oncology research. In her current role as part of the clinical development team in the Molecular Pathology lab at HUP, Sarah designs and validates oncology, infectious disease, and genetic tests to prepare them for clinical use.

    Abstract

    DATE: July 16, 2020

    TIME:  10:00 am PDT

     

    This seminar reviews clinical utility of adopting rapid IDH1/2 testing in both hematological and solid tumors and describes the adjusted workflow developed. Isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are enzymes involved in cellular metabolism and cellular differentiation. Mutations in the IDH1 and IDH2 genes alter their enzymatic activity to produce an oncometabolite. Disease-associated variants in IDH1/2 have clinical implications for multiple forms of cancer. Molecular detection of IDH1 and IDH2 disease-associated variants aids in diagnosis, prognostic stratification, and treatment decisions. For example, detection of IDH variants in acute myeloid leukemia (AML) allows for the addition of IDH-targeted therapies to treatment regimens. Additionally, the diagnosis and prognosis of gliomas are dependent on the IDH1/2 molecular status. In these ways, it is increasingly important to have rapid molecular testing for IDH1/2. Challenges of implementing IDH testing include redundant testing (immunohistochemistry and massively parallel sequencing) and limited specimen material. In order to address these challenges, the clinical utility of rapid IDH1/2 testing was evaluated and modifications to the laboratory workflow were explored. These studies highlight the value of rapid IDH testing and show that procedural adjustments can both streamline laboratory workflows and conserve vital limited specimen material. 

     

    Learning Objectives:

    • Understand the clinical utility of rapid IDH1/2 testing in hematologic neoplasms 
    • Recognize how rapid molecular IDH1/2 testing can aid in the diagnosis of solid tumors 
    • Identify workflow modifications that allow for efficient use of specimens 

     

     

    Webinars will be available for unlimited on-demand viewing after live event.

     

    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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