AUG 21, 2013 7:00 AM PDT

Improving the Accuracy of Genome Sequencing and Interpretation

Speaker

Abstract

Our ability to view and alter biology is progressing at an exponential pace -- faster even than electronics. Next generation sequencing can be used to assess inherited, environmental and epi- genomes. CLIA typically ensures reproducibility, but not necessarily highest accuracy. Genome sequence accuracy requires haplotype phase (measured, not merely inferred). Interpretation accuracy requires deep knowledge of the interactions of genomes, environments and traits. We can now move from mere correlation to causality by systematically synthesizing millions of genomic (and epi-genomic) variants via CRISPR technologies and human pluripotent stem cells. We test these technologies and interpretation software (http://GET-evidence.org ) using data and cells from the world's only fully shareable genomics resource (http://Personalgenomes.org) -- enabling clearer preview of precision medicine. The learning objectives of this session include measuring accuracy of the underlying data, the computational integration of diverse data types -- and informed consent in an era of leaks, rich data and re-identification.


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AUG 21, 2013 7:00 AM PDT

Improving the Accuracy of Genome Sequencing and Interpretation


Specialty

Immunology

Synthetic Biology

Clinical Diagnostics

Cancer Research

Biotechnology

Molecular Diagnostics

Antibodies

Virology

Cellular Mechanism

Genetics

Biochemistry

Dna Sequencing

Personalized Medicine

Immunity

Computational Model

Geography

North America67%

Europe33%

Registration Source

Website Visitors100%

Job Title

Student50%

Medical Laboratory Technician50%

Organization

Academic Institution33%

Clinical Laboratory33%

Contract Research Organization (Cro)33%


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