Laboratory animal surgical models are instrumental in biomedical research; therefore establishing healthy defined animal models is crucial to this research. Surgical procedures produce metabolic changes and stress in animals, which can delay recovery and increase morbidity. A goal of post-operative care is to minimize stress in the animal, thereby improving the ability of the animal to heal and recover. Nutritional supplementation and enrichment have been demonstrated to play a role in improving the post-operative recovery of rodents. Proper nutrition and the administration of post-operative diets and appetite stimulants are critical to laboratory animal recovery and survival post-surgery in order to minimize weight and protein loss and ultimately help the animal maintain body weight and return to a normal metabolic state. An overview of the metabolic effects of surgery on rodent metabolism will be presented. Post-surgical nutritional support, stress-free oral dosing methods, edible enrichment for post-operative monitoring, as well as the rational for including these refinements in rodent surgical procedures will be discussed.
Research And Development
Veterinary Sciences
Animal Research
Animals
Animal Sciences
Lab Animals
Animal Behavior
Drug Development
University
Cancer
Animal Models
Bioinformatics
Flow Cytometry
Health
Immuno-Oncology
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