He founded the Brown Institute of Brain Science at Brown University (Rhode Island, USA) where he spent more than 30 years and where he maintains a professorship. He holds an adjunct professorship at the École Polytechnique Fédérale de Lausanne (EPFL) and is a visiting professor at the University of Geneva (UNIGE) in Switzerland. Prof. Donoghue was also a co-founder of an early neurotechnology startup company, Cyberkinetics. In 2013 his BrainGate neurotechnology, that aims to restore movement for people with paralysis, was recognised by the first Israel B.R.A.I.N. (Breakthrough Research And Innovation in Neurotechnology) prize, as well as the German Zülch ('zoolk') in 2007, the Roche-Nature Medicine in 2010, and the Schrödinger prize in 2012. Prof. Donoghue is a Fellow of several academies including the US Institute of Medicine, the American Academy of Arts and Science, the American Institute for Medical and Biomedical Engineering, the American Association for the Advancement of Science and the Academy of Inventors. He was also a member of the National Institutes of Health Committee for The White House BRAIN Initiative. He has spoken worldwide, including lectures at the World Economic Forum, the Vatican Pontifical Academy of Science and an Alfred Nobel Symposium. His work has been widely featured in the media, including the New York Times, the Economist, the Financial Times, as well as US and international television.