JUL 22, 2015 9:00 AM PDT

WEBINAR: Investigative in vitro Drug Toxicology with Human iPSC-derived Cardiomyocytes

Speakers
  • Product Manager, Cellular Dynamics International, Inc., A FUJIFILM Company
    Biography
      Dr. Anson received his doctorate in Neuroscience from the University of Oregon. His postdoctoral studies at the University of Wisconsin in Molecular Genetics focused on examining structure/function relationships in a variety of K+ channels. He trained under Dr. Craig T. January at the University of Wisconsin Medical School, where he worked as an assistant scientist examining hERG channel physiology and pharmacology in healthy and clinical (Long QT) patients. Dr. Anson has authored over two dozen peer-reviewed manuscripts and book chapters. He began working at Cellular Dynamics International in 2005 as the Director of hERG Screening Services and has been in his current Product Manager role, responsible for numerous iCell® products, since 2009.
    • Scientific Manager, Investigative Toxicology, Safety Assessment, Genentech
      Biography
        Dr. Brock currently oversees in vitro cardiovascular toxicity assays for Genentech's Safety Assessment Dept. He earned his PhD in Neuroscience from Stanford University, where he discovered and characterized a novel class of selective voltage-gated potassium channel blockers. As a postdoc at the NASA Ames Center for Nanotechnology he developed patented technology for solid-state DNA sequencing. He has previously held positions as Sales Scientist and Senior Sales Scientist at AutoMate Scientific and Axion Biosystems respectively, and has authored papers in subjects ranging from potassium channel pharmacology to stem-cell-based modeling of neurodegenerative diseases.

      Abstract:
      DATE: July 22, 2015
      TIME: 9:00AM PT, 12:00PM ET

      Human induced pluripotent stem cells (iPSCs) bring human biology into pre-clinical aspects of drug discovery. iPSC-derived cardiomyocytes have emerged as useful tools for detecting and predicting cardiotoxicity and proarrhythmia. The relevant biology of these cardiomyocytes provides a holistic reagent for testing numerous aspects of structural and functional biology, including on- and off-target toxicities. Syncytial hiPSC-derived cardiomyocytes exhibit highly-regular spontaneous beating with low sample-to-sample variation, which makes them adaptable to real-time functional screening in label-free multiwell platforms and facilitates studies of toxicity mechanisms ranging in time course from minutes to weeks. This webinar brings together speakers from Cellular Dynamics International (CDI) and Genentech to provide an overview of the technology and its implementation, respectively.

      Attendees will learn:

      • The functional human cardiac biology that iPSC-cardiomyocytes bring to the drug discovery arena.

      • Strategies and instrumentation with which iPSC-derived cardiomyocytes are used in hypothesis-driven investigative toxicology studies at Genentech.

      • New functional data on iCell Cardiomyocytes², the newest iteration of iCell Cardiomyocytes from CDI.


      Show Resources
      You May Also Like
      JAN 23, 2020 9:00 AM PST
      C.E. CREDITS
      JAN 23, 2020 9:00 AM PST
      DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
      AUG 27, 2019 9:00 AM PDT
      C.E. CREDITS
      AUG 27, 2019 9:00 AM PDT
      DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
      NOV 18, 2019 7:00 AM PST
      C.E. CREDITS
      NOV 18, 2019 7:00 AM PST
      DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
      SEP 05, 2019 4:00 PM CEST
      C.E. CREDITS
      SEP 05, 2019 4:00 PM CEST
      DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
      OCT 02, 2019 11:00 AM PDT
      OCT 02, 2019 11:00 AM PDT
      DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
      FEB 25, 2020 9:00 AM PST
      Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
      C.E. CREDITS
      FEB 25, 2020 9:00 AM PST
      Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
      Learn about how to generate a small scale CAR-T workflow using ThermoFisher products See detailed characterization tools that can be utilized and applied in a CAR-T workflow...
      Loading Comments...
      Show Resources