MAR 15, 2018 06:00 AM PDT

Keynote Presentation: Reinforcement Learning: Mechanisms and Implications

Presented At Neuroscience 2018
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Professor and Chairman, Department of Neurological Surgery, Albert Einstein College of Medicine, Montefiore Medical Center
    Biography
      Dr. Emad Nader Eskandar, MD, is a Professor and Chairman in the Department of Neurological Surgery at the Albert Einstein College of Medicine, Montefiore Medical Center. He attended and graduated from University Of California, California College Of Medicine in 1993, having over 25 years of diverse experience, especially in Neurosurgery.

    Abstract:

    Reinforcement learning is a critical process though to involve the cortex, striatum, and dopaminergic circuitry.  Work from our group has found that the caudate (Cd) and dorso-lateral prefrontal cortex (DLPFC) encode unexpectedly positive outcomes, consistent with a reward prediction error.  In addition, neurons in both structures encode unexpectedly negative outcomes, which is not yet well-explained.  Moreover, this process is amenable to modulation.  Experiments in rodents, primates, and humans have consistently demonstrated that it is possible to enhance learning with timed stimulation in the Cd.  In animal models of brain injury, this stimulation resulted in accelerated recovery.   Many clinical entities can be conceptualized as disorders of this process, whether it is reduced ability to learn new associations or the inability to replace useless or maladaptive associations such as tics or compulsions. The broader implication is that timed stimulation could be clinically useful in treating disorders beyond brain injury.


    Show Resources
    You May Also Like
    MAY 03, 2018 11:00 AM PDT
    MAY 03, 2018 11:00 AM PDT
    DATE: May 3, 2018TIME: 11:00AM PDT, 2:00PM EDTWhile stress is one of the leading causes of neuropsychiatric disorders, the molecular underpinnings of how stress induces alterations in b...
    APR 27, 2018 10:00 AM PDT
    C.E. CREDITS
    APR 27, 2018 10:00 AM PDT
    DATE: April 27, 2018TIME: 10:00am PST, 1:00pm ESTGlioblastoma (GBM) and Medulloblastoma (MB) are the most common adult and paediatric brain tumours, both of which can have devastating c...
    MAY 02, 2018 08:00 AM PDT
    C.E. CREDITS
    MAY 02, 2018 08:00 AM PDT
    Immunohistochemistry protocols, which utilize antibodies to visualize proteins in tissue sections, have many steps that need optimized to prevent non-specific background effects, artifacts, o...
    MAY 24, 2018 09:30 AM PDT
    C.E. CREDITS
    MAY 24, 2018 09:30 AM PDT
    DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
    AUG 15, 2018 08:00 AM PDT
    C.E. CREDITS
    AUG 15, 2018 08:00 AM PDT
    DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
    JUN 26, 2018 06:00 AM PDT
    C.E. CREDITS
    JUN 26, 2018 06:00 AM PDT
    Date: June 26, 2018Time: 6:00 a.m. PDT, 9:00 a.m. EDT, 1500 CEST Today’s hematology analyzers employ various methods for enumerating platelets. These methods include: e...
    Loading Comments...