MAY 08, 2019 7:30 AM PDT

Keynote Presentation: Interpreting the Zero $ Genome via Base Editing, Organoids & in Situ Omics

C.E. Credits: CEU P.A.C.E. CE Florida CE
Speaker
  • Professor of Genetics, Director of the Center for Computational Genetics, Harvard Medical School
    Biography
      George M. Church, PhD '84, is professor of genetics at Harvard Medical School, a founding member of the Wyss Institute, and director of PersonalGenomes.org, the world's only open-access information on human genomic, environmental, and trait data. Church is known for pioneering the fields of personal genomics and synthetic biology. He developed the first methods for the first genome sequence & dramatic cost reductions since then (down from $3 billion to $600), contributing to nearly all "next generation sequencing" methods and companies. His team invented CRISPR for human stem cell genome editing and other synthetic biology technologies and applications - including new ways to create organs for transplantation, gene therapies for aging reversal, and gene drives to eliminate Lyme Disease and Malaria. Church is director of IARPA & NIH BRAIN Projects and National Institutes of Health Center for Excellence in Genomic Science. He has coauthored 450 papers, 105 patents, and one book, "Regenesis". His honors include Franklin Bower Laureate for Achievement in Science, the Time 100, and election to the National Academies of Sciences and Engineering.

    Abstract

    To interpret genome sequence from telomere to telomere, it is helpful  end-to-end haplotypes with single-molecule epigenetics overlays, via in situ omics at sub-cellular (20 nm) resolution and multicellular (connectome) context.  To test putative causative alleles and therapies, we need faithfully representative organoids and accurate editing of these (not merely NHEJ knockouts).   We also benefit from comprehensive precision medicine datasets on individuals broadly shareable by virtue of either "open consent" protocols (personalgenomes.org) or provably secure queries via homomorphic encryption and blockchain (Nebula.org).  This goals are aided by recent  reduction in cost of human and environmental DNA sequencing by over 10 million fold and new editing tools capable of over 26,000 edits per cell (including tools to read, alter and test changes in DNA repeats).

    Learning Objectives: 

    1. New technologies -- In situ & Nanopore sequencing are moving us toward portable, real-time, inexpensive (0-$999) & gap-less clinical-grade genomes.
    2. Interpretation benefits from testing variants in organoids & large shareable cohorts – enabled by either open consent or secure via homomorphic encryption queries & blockchain public ledgers. 


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