MAY 20, 2020 9:00 AM PDT

Keynote Presentation: Quantitative biology with droplet microfluidics

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor, University of California, San Francisco
    Biography
      Adam Abate graduated from Harvard College in 2002 with an A. B. in Physics. He then received a masters in physics from UCLA in 2004, before moving to the University of Pennsylvania where, in 2006, he received his Ph.D. in Physics studying the physics of soft materials with Douglas Durian. He returned to Harvard for a postdoc in Physics and Engineering in the lab of David Weitz, working on a variety of projects in soft matter physics, chemical and microparticle synthesis, and biological applications of microfluidics. While a postdoc, he developed a droplet-based microfluidic sequencer that became the foundation for the sequencing company GnuBIO. He is now an Assistant Professor at the University of California, San Francisco in the Department of Bioengineering and Therapeutic Sciences (BTS) in the Schools of Medicine and Pharmacy. He is in QB3 and part of the UC Berkeley-UCSF Graduate Program in Bioengineering, PSPG, and iPQB. His research interests are in high-throughput biology with microfluidics, protein engineering through directed evolution, and biophysics.

    Abstract

    Many questions at the forefront of biology depend on the interactions of millions of single cells. My lab develops technologies for studying large numbers of single cells. In this talk, I will describe our approaches for sorting cells based on genomic and transcriptomic markers, and performing multi-omics analysis of single cells that allow simultaneous characterization of genomic, transcriptomic, and proteomic signatures. I will also describe how we are adapting these techniques to integrate genomics with other single cell measurement approaches, including imaging, mass spectrometry, and atomic force microscopy. Finally, I will describe how we are using these techniques to build cells into controlled consortia for microbiological studies and bottom-up tissue synthesis.

    Learning Objectives:

    1. Familiarization with microfluidic methods for single-cell multi-omics analysis

    2. Application of microfluidics to bottom-up cell community assembly


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