SEP 13, 2018 6:00 AM PDT

The Evolution of Diverse, Ubiquitous CRESS DNA Viruses

Speaker
  • Associate Professor, Department of Ecology, Evolution & Natural Resources, Rutgers University

Abstract

Circular, Rep-encoding single-stranded (CRESS) DNA viruses were once thought to be a rare kind of viral genomic architecture.  While some significant agricultural diseases were caused by circoviruses and geminiviruses, they are not typically human pathogens, and it was only when metagenomic methods that were not biased towards double-stranded DNA were widely used did we identify single-stranded DNA viruses  ubiquitously.  Many of these sequence-only identified genomes don’t look like the characterized genera that scientists can grow in the lab, but the one commonality among most of these genomes is that they have a recognizable Replication-associated protein (Rep) that is homologous with all other eukaryote-infecting CRESS DNA viruses.  As we attempt to understand the evolution of this large and speciose group, we have identified idiosyncratic patterns in their nucleotide use, their protein evolution and have created a Rep genealogy that represents the evolution of their shared ORF.  Recently systematized groups of CRESS DNA viruses have not plumbed the depths of the uncharacterized viral diversity that has been sequenced, and the Rep tree suggests that existing families of CRESS DNA viruses may not be independently evolving — we suggest there is a common origin of the intron in the Rep of some geminiviriuses and all gemonoviruses. CRESS DNA viruses are a newly discovered component of microbiomes across eukaryotes and in environmental samples, and we are starting to understand how these pathogens have diversified over evolutionary time.

Learning Objectives: 

1. Appreciate the ecological and molecular diversity of CRESS DNA viruses that infect eukaryotes.
2. Understand how the molecular evolution of unique groups of viruses differ from one another, and the value of accurate model choice in phylogenetics.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
APR 21, 2021 10:00 AM PDT
C.E. CREDITS
APR 21, 2021 10:00 AM PDT
Date: April 21, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Serological testing for SARS-CoV-2 has been steadily adopted into clinical practice over the course of this pandemic. In this webinar,...
JUL 13, 2021 11:00 AM PDT
C.E. CREDITS
JUL 13, 2021 11:00 AM PDT
Date: July 13, 2021 Time: 11:00am (PDT), 1:00pm (EDT) 1 R&D, Cell Culture & Fermentation Sciences, Bio Pharmaceutical Development, AstraZeneca, Gaithersburg, USA, 2 R&D, ADPE, Ce...
JUL 15, 2021 8:00 AM PDT
C.E. CREDITS
JUL 15, 2021 8:00 AM PDT
Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
SEP 13, 2018 6:00 AM PDT

The Evolution of Diverse, Ubiquitous CRESS DNA Viruses


Specialty

Animal Behavior

Chemistry

Genomics

Animal Research

Cell Biology

Gene Sequencing

Systems Biology

Cancer Diagnostics

Dna Sequencing

Oncology

Biomarkers

Diagnostics

Molecular Biology

Research

Assay Development

Geography

Asia100%

Registration Source

Website Visitors100%

Job Title

Educator/Faculty50%

Medical Laboratory Technician50%

Organization

Academic Institution50%

Manufacturer - Other50%


Show Resources
Loading Comments...
Show Resources