FEB 03, 2016 9:00 AM PST

Keynote: Risks of Bias in in vivo research - and what to do about them

Speaker

Abstract

Translational failure in biomedicine has led to much soul-searching about the causes for this. Amongst many others (misunderstanding of statistical tests, vibration of effects, flexibility in data analysis, HARKing) there is a primary problem with bias in the way in which animal studies are planned, conducted and analysed. Reporting of measures to reduce the risk of bias  is poor, and the most parsimonious explanation for this is that the measures were not taken (rather than not reported). Studies at such risk of bias give inflated estimates of biological effects. 
Risk of bias is a pervasive problem across institutions, journals, and research fields, and attempts to improve research quality have, to date, had little apparent effect. It seems that “on the street”, scientists still feel that the pressure to publish novel findings in journals of high impact is substantially greater than the pressure to conduct their research to the highest (or even to moderately high) quality; and in response to these competing pressures research quality remains low. 
To secure greatest value from the resources invested in research (including animals), this needs to be changed.

Two Learning Objectives

  1. Participants will understand the importance, and prevalence, of reporting of measures to reduce the risks of bias in in vivo research
  2. Participants will be aware of some of the proposed strategies to improve the quality of in vivo research

Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
FEB 24, 2021 10:00 AM PST
C.E. CREDITS
FEB 24, 2021 10:00 AM PST
DATE: February 24, 2021 TIME: 10am PST Automated lab instruments such as liquid handlers and cell sorters are increasingly common in all types of laboratories, driving fast results for labor...
APR 21, 2021 10:00 AM PDT
C.E. CREDITS
APR 21, 2021 10:00 AM PDT
Date: April 21, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Serological testing for SARS-CoV-2 has been steadily adopted into clinical practice over the course of this pandemic. In this webinar,...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
FEB 03, 2016 9:00 AM PST

Keynote: Risks of Bias in in vivo research - and what to do about them


Specialty

Animal Sciences

Animal Behavior

Drug Discovery

Animal Models

Animal Research

Biotechnology

Dna Sequencing

Personalized Medicine

Cell Culture

Immunity

Biomarkers

Immunotherapy

Flow Cytometry

Molecular Biology

Immuno-Oncology

Geography

Europe83%

North America17%

Registration Source

Website Visitors100%

Job Title

Research Scientist33%

Medical Laboratory Technician33%

Student17%

Facility/Department Manager17%

Organization

Academic Institution50%

Clinical Laboratory17%

Contract Research Organization (Cro)17%

Pharmaceutical Company17%


Show Resources
Loading Comments...
Show Resources