FEB 04, 2016 09:00 AM PST

Keynote: The ARRIVE guidelines: Improving the design and reporting of animal research to optimize the reproducibility of animal studies

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  • Science Manager, National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs)
      Katie Lidster is Science Manager at the National Centre for the 3Rs. Katie obtained her BSc in Biological Sciences at the University of Edinburgh, followed by an MSc in Drug Discovery Skills at Kings College London with an industrial placement at GlaxoSmithKline. She then completed a PhD in Neuroimmunology in 2010 developing a refined animal model to study neuroprotective therapies for multiple sclerosis and continued working in the lab as a Post-Doctoral Research Associate. Katie joined the NC3Rs in 2013 and works within the Research Management and Policy group and is currently the lead for the ARRIVE guidelines aimed at improving the reporting of animal research.


    The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is leading an initiative to improve the design and reporting of animal research. The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines (www.nc3rs.org.uk/ARRIVE) were developed in consultation with scientists, statisticians, journal editors and research funders with the aim to maximise information published and minimise unnecessary animal studies. The guidelines consist of a checklist of 20 items, which researchers can use when designing and reporting scientific experiments to ensure animal studies are robust, transparent and reproducible. Over 600 journals, major research funders, universities and learned societies endorse the guidelines and the recent translation of the guidelines into popular languages, has contributed to their widespread international adoption. Following on from the ARRIVE guidelines, the NC3Rs has developed the Experimental Design Assistant (https://eda.nc3rs.org.uk), an online tool to help guide researchers through the design and analysis of their experiments to improve the robustness and transparency of animal studies and ensure the minimum number of animals is used to reach the scientific objectives of the study.

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