MAY 24, 2017 1:30 PM PDT

Lab-on-a-printer™ - a multi-material 3D bioprinting platform for building living tissues on demand

Presented at: Lab Automation 2017
Speaker
  • Chief Scientific Officer & Co-Founder, Aspect Biosystems
    Biography
      Sam Wadsworth, Ph.D., Chief Scientific Officer & Co-Founder Aspect Biosystems. Imagine a world where drugs are developed without the use of animals, and where replacement organs are 3D printed from a patient's own cells, rather than being donated. Sam is working towards making this a reality, he is a world leader in the field of human airway tissue engineering and has published many peer-reviewed papers on related research. After completing his Ph.D. in respiratory cell biology in the UK, Sam moved to Vancouver, BC for a Post-Doc at the UBC Centre for Heart + Lung Innovation at St. Paul's Hospital, where he spearheaded an inter-disciplinary, cross-Canada research project to build living 3-Dimensional human airway tissues. In 2013 Sam co-founded Aspect Biosystems with Konrad Walus, Simon Beyer and Tamer Mohamed. Aspect is a tissue engineering company with proprietary 3D-bioprinting technology capable of fabricating a variety of physiologically-relevant human tissues. Sam will be discussing Aspect's unique Lab-on-a-Printer technology, and will describe how this has the potential to revolutionise the fields of pharmaceutical drug development, disease research, and regenerative medicine by providing living human tissues on demand.

    Abstract

    Drug development is a costly and time consuming process, poor translation of data from pre-clinical studies to the clinic is a major contributor as late-stage drug failure is very expensive. Testing drugs in 3D tissues that better represent human organ physiology and function may help reduce the cost of drug development by improving translation to the clinic. 


    In order to mimic the complex heterogeneity and microstructure of tissue, we are developing a novel 3D bioprinting paradigm called Lab-on-a-PrinterTM (LOP). The LOP concept involves integration of microfluidic liquid manipulation directly with filament deposition technology, this enables rapid switching between different cell-containing bioink compositions and the ability to multiplex several materials in a single printhead.


    The LOP platform technology is capable of generating multi-material cell-loaded 3D hydrogel constructs using fused filament fabrication (FFF). Our system uses co-axial flow focusing, a process whereby cells within printed fibres are protected from the damaging shear forces present in many alternative bioprinting strategies. We are thus able to use LOP to generate fibres with very high cell density while printing at high fibre speeds without sacrificing cell viability. 
    The LOP system can generate fibres containing a variety of extracellular matrix factors, growth factors, cytokines, and other bioactive compounds. The user can customise bioinks to optimise the cellular microenvironment in a region specific way within a single tissue construct. 


    I will discuss how Aspect and our collaborators are using the LOP technology to generate a variety of unique functional 3D human tissues for use as pre-clinical testing tools in indications such as asthma, hypertension, premature birth and neurodegenerative disease. Printing tissues on demand will have significant impact for regenerative medicine, I will describe how LOP technology is being used to develop implantable orthopaedic tissues to improve quality of life for patients with joint injuries.
     


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