MAY 24, 2017 1:30 PM PDT

Lab-on-a-printer™ - a multi-material 3D bioprinting platform for building living tissues on demand

Presented at: Lab Automation 2017
Speaker

Abstract

Drug development is a costly and time consuming process, poor translation of data from pre-clinical studies to the clinic is a major contributor as late-stage drug failure is very expensive. Testing drugs in 3D tissues that better represent human organ physiology and function may help reduce the cost of drug development by improving translation to the clinic. 


In order to mimic the complex heterogeneity and microstructure of tissue, we are developing a novel 3D bioprinting paradigm called Lab-on-a-PrinterTM (LOP). The LOP concept involves integration of microfluidic liquid manipulation directly with filament deposition technology, this enables rapid switching between different cell-containing bioink compositions and the ability to multiplex several materials in a single printhead.


The LOP platform technology is capable of generating multi-material cell-loaded 3D hydrogel constructs using fused filament fabrication (FFF). Our system uses co-axial flow focusing, a process whereby cells within printed fibres are protected from the damaging shear forces present in many alternative bioprinting strategies. We are thus able to use LOP to generate fibres with very high cell density while printing at high fibre speeds without sacrificing cell viability. 
The LOP system can generate fibres containing a variety of extracellular matrix factors, growth factors, cytokines, and other bioactive compounds. The user can customise bioinks to optimise the cellular microenvironment in a region specific way within a single tissue construct. 


I will discuss how Aspect and our collaborators are using the LOP technology to generate a variety of unique functional 3D human tissues for use as pre-clinical testing tools in indications such as asthma, hypertension, premature birth and neurodegenerative disease. Printing tissues on demand will have significant impact for regenerative medicine, I will describe how LOP technology is being used to develop implantable orthopaedic tissues to improve quality of life for patients with joint injuries.
 


Show Resources
You May Also Like
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
JUN 28, 2022 7:00 AM PDT
JUN 28, 2022 7:00 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
APR 26, 2022 7:00 AM PDT
C.E. CREDITS
APR 26, 2022 7:00 AM PDT
Date: April 19, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) High-content (HC) phenotypic profiling approaches are a powerful tool to study the effect of biological, genetic, and ch...
MAY 17, 2022 9:00 AM PDT
MAY 17, 2022 9:00 AM PDT
Date: May 17, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 8:00pm (CEST) Gene therapeutics have great potential to treat many severe diseases in an unprecedented, targeted manner. The biopharmace...
MAR 16, 2022 8:00 AM PDT
C.E. CREDITS
MAR 16, 2022 8:00 AM PDT
Date: March 16, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CET) Handling of potent and/or hazardous substances is commonplace in sev.....
OCT 12, 2022 9:00 AM PDT
C.E. CREDITS
OCT 12, 2022 9:00 AM PDT
Date: October 12, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) The microbiome of every food product is incredibly diverse and can include everything from innocuous background flora...
MAY 24, 2017 1:30 PM PDT

Lab-on-a-printer™ - a multi-material 3D bioprinting platform for building living tissues on demand

Presented at: Lab Automation 2017


Show Resources
Loading Comments...
Show Resources