Concerted efforts over past decades have established a thorough understanding of the canonical somatic DNA methylation landscape as well as its systematic misregulation across many cancers. However, the underlying mechanisms that may direct this genome-scale transformation remains elusive, with no clear model for its acquisition or understanding of its potential developmental utility. I will first summarize work from the past decade that provided key insights into our general understanding of DNA methylation and then discuss recent data that provide evidence for a developmental origin of the shared, erratic cancer methylome.
Biotechnology
Molecular Biology
Cancer Research
Cell Biology
Genetics
Biomarkers
Molecular Diagnostics
Dna
Genomics
Cell Culture
Cancer Diagnostics
Biochemistry
Clinical Diagnostics
Immunology
Laboratory Testing
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