NOV 09, 2017 02:00 AM PST

Mammalian DNA methylation landscapes and human cancers

Speakers
  • Director, Max Planck Institute for Molecular Genetics
    Biography
      Alexander Meissner studied Medical Biotechnology at the Technical University Berlin before starting his PhD studies with Rudolf Jaenisch at the Whitehead Institute/MIT in 2002. He completed his PhD in 2006 and spent the next year and a half working with Rudolf Jaenisch and Eric Lander before starting his own lab as an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University and as an associate member of the Broad Institute in 2008. He was promoted to associate professor in 2012 and full professor with tenure in 2015. In 2016 he has been appointed as Director and Head of the Department of Genome regulation at the Max Planck Institute for Molecular Genetics in secondary employment and changed it to his principal employment in 2017.

    Abstract:

    Concerted efforts over past decades have established a thorough understanding of the canonical somatic DNA methylation landscape as well as its systematic misregulation across many cancers. However, the underlying mechanisms that may direct this genome-scale transformation remains elusive, with no clear model for its acquisition or understanding of its potential developmental utility. I will first summarize work from the past decade that provided key insights into our general understanding of DNA methylation and then discuss recent data that provide evidence for a developmental origin of the shared, erratic cancer methylome.


    Show Resources
    You May Also Like
    NOV 18, 2019 07:00 AM PST
    C.E. CREDITS
    NOV 18, 2019 07:00 AM PST
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    JAN 23, 2020 09:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JAN 23, 2020 09:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: TIME: adadf adfadf...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    FEB 25, 2020 09:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    FEB 25, 2020 09:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Learn about how to generate a small scale CAR-T workflow using ThermoFisher products See detailed characterization tools that can be utilized and applied in a CAR-T workflow...
    DEC 10, 2019 09:00 AM PST
    C.E. CREDITS
    DEC 10, 2019 09:00 AM PST
    DATE: December 10, 2019TIME: 9:00am PST, 12:00pm EST A major limitation in the ex vivo expansion of harvested human hematopoietic stem-progenitor cells (HSPCs) is the rapid dif...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    Loading Comments...
    Show Resources