FEB 08, 2018 12:00 PM PST

Data Collection as Environmental Enrichment: Automated Behavioral Measurement in Voluntary Home Cage Operant Tasks

Speaker

Abstract

Biomedical research suffers from a translation gap, where most treatments that seem effective when tested on animals turn out not to work in human patients. This is likely due in large part to differences in how animal and human experiments are performed, and a key step in overcoming this problem is to treat animals like we treat human patients. This means making their well-being a top priority and giving them control over stressors in their housing and testing environments.

Cognitive tests of learning and memory are typically performed in an operant chamber outside of the home cage. Many of the aversive features of these hand-run tests – handling by experimenters, temporary separation from social companions, and being placed in unfamiliar environments – can be eliminated by testing animals on a voluntary basis, inside their home cages. Automated home cage operant tests further help ensure that animals volunteer to be tested only when appropriately motivated. Properly designed tests that tap into animals’ intrinsic motivations and match the level of cognitive challenge to their level of skill can even be a valuable form of environmental enrichment.

Aversive features and low or fluctuating motivation associated with conventional hand-run operant tests can negatively impact cognitive performance. Automated home cage operant tests may then more accurately assess learning and memory. Large-scale replication studies further suggest that results of these tests are more consistent across different laboratories. By yielding control to experimental animals and allowing them to be tested voluntarily rather than through coercion, automated home cage operant tests may additionally pave the way towards improved translation from animal to human patients. If so, this would serve as a prime example of how good animal welfare can lead to good science, with improved quality of life for experimental animals and accelerated development of treatments for human patients.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUL 15, 2021 8:00 AM PDT
C.E. CREDITS
JUL 15, 2021 8:00 AM PDT
Date: July 15, 2021 Time: 8:00am (PDT), 11:00am (EDT) High dimensional full spectrum flow cytometry grants unprecedented access to previously unattainable parameters in cellular biology. Flu...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
OCT 27, 2021 6:00 AM PDT
C.E. CREDITS
OCT 27, 2021 6:00 AM PDT
Date: October 27, 2021 Time: 6:00 AM PDT, 9:00 AM EDT Etanercept is a recombinant Fc fusion protein therapeutic that has a complex distribution of post-translation modifications (PTM), such...
FEB 08, 2018 12:00 PM PST

Data Collection as Environmental Enrichment: Automated Behavioral Measurement in Voluntary Home Cage Operant Tasks


Specialty

Animal Research

Animal Models

Animals

Animal Sciences

Veterinary Sciences

Animal Behavior

Neurobiology

Cell

Life Science

Genetics

Molecular Neuroscience

Animal Welfare

Research

University

Cancer Research

Geography

Europe81%

North America13%

Asia3%

Registration Source

Website Visitors100%

Job Title

Student23%

Medical Doctor/Specialist19%

Medical Laboratory Technician15%

Executive12%

Animal Care Lab Technician8%

Post Doc8%

Facility/Department Manager4%

Research Scientist4%

Scientist4%

Chemist4%

Organization

Academic Institution56%

Hospital16%

Research Institute9%

Government3%

Non-Profit Organization3%

Ambulatory Care3%

Manufacturer - Other3%

Pharmaceutical Company3%


Show Resources
Loading Comments...
Show Resources