SEP 13, 2017 6:00 AM PDT

Microbe Wars: The Rise of CRISPR Immunity and Technology

Speaker

Abstract

Prokaryotes have long been at war with bacteriophage. The evolutionary pressure of this struggle has led both sides to develop sophisticated defenses. Notably, CRISPR-Cas systems evolved to let bacteria and archaea record past infections and rapidly squelch subsequent viral invasions. First, CRISPR proteins capture nucleic acids to build a genomic gallery of "molecular mugshots." Next, the mugshots are printed into RNA copies and distributed amongst CRISPR interference proteins. These RNA-guided bounty hunters precisely identify and cleave offending genomes to halt infection. No system is fool-proof, however, and recent work has elucidated an impressive arsenal of "anti-CRISPR" proteins that bacteriophage deploy to evade destruction. Studying this on-going arms race has yielded a treasure trove of biotechnology tools. I will discuss the stages of CRISPR immunity while highlighting how scientists have co-opted its various proteins for diverse applications.


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SEP 13, 2017 6:00 AM PDT

Microbe Wars: The Rise of CRISPR Immunity and Technology


Specialty

Microbiology

Cell Culture

Immunology

Gene Expression

Pharmacology

Dna

Cancer Research

T-Cells

Infectious Disease

Biotechnology

Virology

Research

Cancer Diagnostics

Infection

Earth Sciences

Geography

North America33%

Asia33%

Europe33%

Registration Source

Website Visitors100%

Job Title

Student33%

Microbiologist17%

QC/QA17%

Research Scientist17%

Medical Laboratory Technician17%

Organization

Research Institute33%

Government/public17%

Manufacturer - Other17%

Academic Institution17%

Other17%


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