SEP 13, 2017 6:00 AM PDT

Microbe Wars: The Rise of CRISPR Immunity and Technology

Speakers
  • Science Communications Manager, Innovative Genomics Institute
    Biography
      Megan has a B.A. in Biology from Brown University and received her Ph.D. from Jennifer Doudna's lab at UC Berkeley in 2016, where she studied mechanisms of CRISPR immunity in bacteria. She joined the IGI in September 2016 to handle scientific communications, hoping to bridge the gap between researchers and the public.

    Abstract:

    Prokaryotes have long been at war with bacteriophage. The evolutionary pressure of this struggle has led both sides to develop sophisticated defenses. Notably, CRISPR-Cas systems evolved to let bacteria and archaea record past infections and rapidly squelch subsequent viral invasions. First, CRISPR proteins capture nucleic acids to build a genomic gallery of "molecular mugshots." Next, the mugshots are printed into RNA copies and distributed amongst CRISPR interference proteins. These RNA-guided bounty hunters precisely identify and cleave offending genomes to halt infection. No system is fool-proof, however, and recent work has elucidated an impressive arsenal of "anti-CRISPR" proteins that bacteriophage deploy to evade destruction. Studying this on-going arms race has yielded a treasure trove of biotechnology tools. I will discuss the stages of CRISPR immunity while highlighting how scientists have co-opted its various proteins for diverse applications.


    Show Resources
    You May Also Like
    SEP 05, 2019 4:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 4:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    NOV 18, 2019 7:00 AM PST
    C.E. CREDITS
    NOV 18, 2019 7:00 AM PST
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    AUG 27, 2019 9:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 9:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    DEC 05, 2019 9:00 AM PST
    C.E. CREDITS
    DEC 05, 2019 9:00 AM PST
    DATE: December 5, 2019TIME: 9:00am PST, 12:00pm EST Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues e...
    Loading Comments...
    Show Resources
    Attendees