SEP 23, 2020 6:00 AM PDT

Keynote Presentation: MicroRNAs in Extracellular Vesicles orchestrate the biology of the Tumor Microenvironment

Presented at: Cell Biology 2020
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor, Co-Leader Cancer Biology Program, University of Hawai'i Cancer Center
    Biography

      Dr. Muller Fabbri is Associate Professor and co-Leader of the Cancer Biology Program at the University of Hawai'i Cancer Center (UHCC) in Honolulu, HI, USA. He also is the Scientific Lead of the Micro- and Nano-Scale Cancer Therapeutics Initiative at UHCC. Dr. Fabbri has provided the first evidence that microRNAs delivered to surrounding cells of the Tumor Microenvironment through extracellular vesicles can bind to Toll-like receptors and trigger downstream signaling pathways highly impactful on cancer biology. Dr. Fabbri is author of more than 90 peer reviewed publications, he has authored several book chapters, serves in the Editorial Board of many international scientific Journals. Dr. Fabbri's lab is focused on studying how microRNAs (and other non-coding RNAs) are communicating between cancer cells and surrounding cells of the tumor microenvironment and how this affects cancer biology and the development of resistance to chemo and radiotherapy.


    Abstract

    MicroRNAs (miRs) are small non-coding RNAs whose expression is altered in several types of human cancers. Recent evidence supports their inter-cellular transfer through extracellular vesicles (EVs) secreted both by the cancer cells and by the surrounding cells of the Tumor Microenvironment (TME). These findings have suggested that the behavior of cancer cells can be significantly modified by the cross-talk with the surrounding TME as mediated by the exchange of EV-miRs. This lecture will focus on some of the most relevant implications of vesicular miRs in the biology of cancer cells and its surrounding TME.

    Learning Objectives:

    1. Explain how to classify different types of Extracellular Vesicles

    2. Identify different possible outcomes of miR transfer to and from cancer cells

    3. Learn how to exploit this knowledge to identify new therapeutic targets


    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    APR 01, 2021 8:00 AM PDT
    C.E. CREDITS
    APR 01, 2021 8:00 AM PDT
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    Loading Comments...
    Show Resources
    Attendees
    • See more