Associate Professor of Surgery, Division of Adult Cardiothoracic Surgery, Chief of General Thoracic Surgery, University of California, San Francisco, VA Medical Center
Michael J. Mann, M.D. is a leader in the development of genetic and molecular therapies and diagnostics for thoracic and cardiovascular disease. Dr. Mann joined the UCSF Thoracic Oncology Program in 2003 as a cardiothoracic surgeon. He had received an A.B. in synthetic chemistry from Princeton University and an M.D. from Stanford University, and was awarded a Ruth L. Kirschstein National Research Service Award (NRSA) Research Training Fellowship through the NIH. Dr. Mann completed his General Surgery residency at Brigham and Women's Hospital/Harvard Medical School, where he also served on the Faculty of Cardiovascular Medicine, and completed his Cardiothoracic Surgery fellowship at UCSF. Dr. Mann is widely admired for his teaching skills and is Associate Director of the Thoracic Surgery Training Program at UCSF. He holds memberships in numerous professional organizations, including the Society of Thoracic Surgeons, American College of Surgeons, American Heart Association, and the Massachusetts Medical Society. Highly respected by his peers, Dr. Mann was named to the list of U.S. News "Top Doctors;" his areas of clinical expertise include lung cancer, management of metastatic disease in the chest, sarcoma, mesothelioma, and minimally invasive (video-assisted) thoracoscopic surgery. He has received numerous awards including the Cardiovascular Medicine Award for Excellence in Research and the William Randolph Hearst Endowment for Young Investigators. Dr. Mann also serves as a scientific reviewer for numerous professional journals.
While on the faculty at Harvard Medical School, Dr. Mann founded the Cardiovascular Gene Therapy Group. He also invented several novel drug and delivery technologies and helped pioneer the application of gene regulation and vascular biology principles to the problem of coronary bypass graft failure. This led to one of the first large scale programs to evaluate the surgical integration of an advanced molecular therapy. More recently, Dr. Mann's focus on oncogenic signaling pathways and molecular profiles of lung cancer and sarcoma has led to the development and international validation of a molecular diagnostic assay that has enabled personalization of the management of early stage lung cancer. Dr. Mann's research in genetic and molecular therapies has been widely recognized, and he is a founder of the first international co-operative study group designed to harness immense untapped clinical research resources in mainland China. He is currently an Associate Investigator in the UCSF Cardiovascular Research Institute, has served as a scientific advisor to the American Heart Association, to the NIH Recombinant-DNA Advisory Committee and to numerous device and pharmaceutical companies, and his Cardiothoracic Translational Research Laboratory has enjoyed continuous NIH R01 funding since its founding in 2006.