Dr. Sigrid Reinsch will discuss NASA’s GeneLab Project whose goal is to develop a unique publicly accessible repository and collaborative workspace that hosts multi-omics datasets generated through biological experiments flown in space. Dr. Reinsch will discuss the mission of GeneLab within the context of NASA’s Space Biology Project and the longer term goals for space exploration. She will then detail how the database is structured, and the unique challenges of generating and analyzing spaceflight omics data. She will discuss the Systems Biology approaches currently used to understand the Omics results from space flight model systems (rodent, fruit fly etc) in the context of tissue response (i.e. muscle, liver, other vital organs). Strategies regarding how GeneLab envisions the involvement of the scientific community and the public at large will also be presented, with current and future capabilities of the system. Anyone interested in how omics technologies can enable space exploration, or who is curious to understand how space modifies living organisms should attend.