MAR 15, 2017 10:30 AM PDT

Neurocartography in the era of Big Data

Presented at: Neuroscience 2017
Speaker
  • Assistant Professor, University of Chicago
    Biography
      Dr. Kasthuri is a Neuroscience Researcher at Argonne National Labs and an Assistant Professor (Part-Time) in the Dept. of Neurobiology, University of Chicago. He has an MD from Washington University School of Medicine and a D.Phil. from Oxford University where he studied as a Rhodes scholar. The Kasthuri lab is pioneering new techniques for large volume reconstructions of the fine structure of the nervous system - 'connectomics'. These developments include: large volume automated electron microscopy for mapping neuronal connections, synchrotron source X-ray microscopy to map the cellular composition of entire brains; improving sample preparation in order to increase the efficiency of automated algorithmic tracing of these datasets; and combining electron microscopy with current techniques for interrogating the proteome and the genome. These tools will be applied in the service of answering the question: how do brains change as they grow up? In particular, the lab is interested in how changes in the micro biome affect the structure and the function of developing neurons in the periphery (e.g. in the enteric nervous system) and in the brain.

    Abstract

    Dr. Kasthuri is a Neuroscience Researcher at Argonne National Labs and an Assistant Professor (adjunct) in the Dept. of Neurobiology, University of Chicago.  He has an MD from Washington University School of Medicine and a D.Phil. from Oxford University where he studied as a Rhodes scholar.  As a post-doctoral fellow, Dr. Kasthuri developed an automated approach to large volume serial electron microscopy (‘connectomics’).  Currently, the Kasthuri lab continues to innovate new approaches to brain mapping  including making connectomics samples more amenable to automatic segmentation and combining proteomic and genomic approaches with electron microscopy.  We are also now exploring the use of high-energy x-rays from synchrotron sources for mapping brains in their entirety. The Kasthuri lab is applying these techniques to developing, adult, and aged brains in service of answering the question: how do brains grow up and age?


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