MAR 15, 2017 10:30 AM PDT

Neurocartography in the era of Big Data

Presented at: Neuroscience 2017
Speaker
  • Assistant Professor, University of Chicago
    Biography
      Dr. Kasthuri is a Neuroscience Researcher at Argonne National Labs and an Assistant Professor (Part-Time) in the Dept. of Neurobiology, University of Chicago. He has an MD from Washington University School of Medicine and a D.Phil. from Oxford University where he studied as a Rhodes scholar. The Kasthuri lab is pioneering new techniques for large volume reconstructions of the fine structure of the nervous system - 'connectomics'. These developments include: large volume automated electron microscopy for mapping neuronal connections, synchrotron source X-ray microscopy to map the cellular composition of entire brains; improving sample preparation in order to increase the efficiency of automated algorithmic tracing of these datasets; and combining electron microscopy with current techniques for interrogating the proteome and the genome. These tools will be applied in the service of answering the question: how do brains change as they grow up? In particular, the lab is interested in how changes in the micro biome affect the structure and the function of developing neurons in the periphery (e.g. in the enteric nervous system) and in the brain.

    Abstract

    Dr. Kasthuri is a Neuroscience Researcher at Argonne National Labs and an Assistant Professor (adjunct) in the Dept. of Neurobiology, University of Chicago.  He has an MD from Washington University School of Medicine and a D.Phil. from Oxford University where he studied as a Rhodes scholar.  As a post-doctoral fellow, Dr. Kasthuri developed an automated approach to large volume serial electron microscopy (‘connectomics’).  Currently, the Kasthuri lab continues to innovate new approaches to brain mapping  including making connectomics samples more amenable to automatic segmentation and combining proteomic and genomic approaches with electron microscopy.  We are also now exploring the use of high-energy x-rays from synchrotron sources for mapping brains in their entirety. The Kasthuri lab is applying these techniques to developing, adult, and aged brains in service of answering the question: how do brains grow up and age?


    Show Resources
    You May Also Like
    DEC 02, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    SEP 02, 2020 7:00 AM PDT
    C.E. CREDITS
    SEP 02, 2020 7:00 AM PDT
    DATE: September 2, 2020 TIME: 03:00pm PDT, 6:00pm EDT Spatial omics is an expanding collection of methods to examine biological molecules in their geographical context. By retaining the prec...
    DEC 16, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    DEC 16, 2020 8:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: December 16, 2020 Time: 8:00am (PST), 11:00am (EST) Molecular imaging of living specimens offers a means to draw upon the growing body of high-throughput molecular data to better under...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    Loading Comments...
    Show Resources