NOV 12, 2015 01:30 PM PST

NGS in clinical research

Speakers
  • Senior Global Product Manager, NGS, Qiagen
    Biography
      Jennifer Fostel has her masters in Molecular and Cell Biology from University of California at Berkeley. She did her graduate research in Dr. Susan Marqusee's lab where she analyzed the key properties of proteins from thermophilic and mesophilic microbial species. She has worked in next-generation sequencing for the last seven years, including management of clinical next generation sequencing projects for the Broad Institute of MIT and Harvard as well as NGS biomarker assay development for Takeda Pharmaceuticals oncology translational medicine. Today at QIAGEN Jennifer is a Senior Global Product Manager, covering a portfolio of universal workflow NGS library preparation products.

    Abstract:

    Currently, next-generation sequencing is not only being used for basic discovery research but also in clinical settings for translational biomarker profiling and clinical research studies including inherited diseases and cancer.   Implementing a clinical-grade NGS assay is complex as it requires expertise in technology, medicine, and bioinformatics, and as a result, clinical standards for NGS are still being established by regulatory agencies and disease communities.   In addition to technical expertise, there are other strategic decisions that need to be made prior to implementing an NGS assay in a clinical environment.  These include selecting the most appropriate NGS assay for the clinical purpose, laboratory validation of the assay, and choosing a partner lab if you intend to outsource sequencing. The webinar will provide an introduction to some of these questions in NGS clinical research. 

    In this webinar you will learn
    1.    How NGS data differs from array or qPCR assays
    2.    Strategies for NGS sequencing: WGS, WES and Targeted DNA sequencing 
    3.    Considerations for validating an NGS assay for clinical use


    Show Resources
    You May Also Like
    MAY 22, 2018 08:00 AM PDT
    C.E. CREDITS
    MAY 22, 2018 08:00 AM PDT
    DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
    MAY 24, 2018 09:30 AM PDT
    C.E. CREDITS
    MAY 24, 2018 09:30 AM PDT
    DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
    MAY 03, 2018 11:00 AM PDT
    MAY 03, 2018 11:00 AM PDT
    DATE: May 3, 2018TIME: 11:00AM PDT, 2:00PM EDTWhile stress is one of the leading causes of neuropsychiatric disorders, the molecular underpinnings of how stress induces alterations in b...
    APR 27, 2018 10:00 AM PDT
    C.E. CREDITS
    APR 27, 2018 10:00 AM PDT
    DATE: April 27, 2018TIME: 10:00am PST, 1:00pm ESTGlioblastoma (GBM) and Medulloblastoma (MB) are the most common adult and paediatric brain tumours, both of which can have devastating c...
    AUG 15, 2018 08:00 AM PDT
    C.E. CREDITS
    AUG 15, 2018 08:00 AM PDT
    DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
    JUN 20, 2018 10:00 AM EDT
    C.E. CREDITS
    JUN 20, 2018 10:00 AM EDT
    DATE: June 20, 2018TIME: 07:00AM PDT, 10:00AM EDTIntroducing GE’s New Lyo-StableTM service. Sepsis is one of the top challenges facing hospitals in terms of clinical outcomes...
    Loading Comments...