JUL 29, 2016 01:00 AM PDT

NMR-based tools in Clinical Research and Biobanking

SPONSORED BY: Bruker, Bruker
  • Senior Pediatric consultant, Department of Translational Medicine, University Childrens Hospital Heidelberg
      Prof. Dr. med. Friedrich Trefz was born on January 20th 1945 in Heidelberg, Germany. After his high school graduation in 1965 he did 2 years of military service before he started with his medical studies in Freiburg and Heidelberg in 1967. After the medical board examination in 1972 he started his research at the Children's Hospital, University of Heidelberg where he also wrote his medical thesis in 1976. 1983 he received his pediatrician degree and started a habilitation ("In vivo determination of the activity of the phenylalanine hydroxylating system. Relevance of the method for the differential diagnosis of phenylketonuria and its variants"). 2 years later Professor Trefz was nominated as associate Professor for pediatrics and started as head of the pediatric metabolic disease department, where he worked until 1992. Before he started at Kreiskliniken Reutlingen, School of Medicine, University of Tuebingen in 1992 he got a grant from Federal Ministry of Education and Research for "Principal Investigator German Maternal PKU Study. Since April 2015 he is working as senior pediatric consultant at the department of translational medicine, University Childrens Hospital Heidelberg.
    • CTO of the Applied, Industrial and Clinical Division at Bruker BioSpin, Bruker
        Dr. Manfred Spraul was born on January 29th 1953 in Karlsruhe, Germany. He did his diplomen in chemistry at Technical University in Karlsruhe and the PHD work in the Engler Bunte Institute of the University, section Petrochemistry.1982 Dr. Spraul joined Bruker Analytische Messtechnik (now called Bruker BioSpin GmbH) as application chemist for NMR and LC. After three years he was appointed as manager of NMR application group in Rheinstetten, Germany. From 2002 until 2012 he was director of NMR applications and worldwide coordinator of Hyphenation. Since January 2015 he is the CTO (chief technology officer of the Applied, Industrial and Clinical Division AIC at Bruker BioSpin.
        Dr. Spraul is member of the executive committee of the NIHR Phenome Center Network and part of the Scientific Committee of the MR in Food Society. He has been participating in over 100 publications in the field of NMR and mixture analysis and has been contributing to 14 patents on NMR and Hyphenation, High Throughput Screening and Data Analysis.

      DATE:  July 29th, 2016
      TIME:  10am Berlin time, 4pm Beijing time

      One of the major benefits of In-Vitro Diagnostic Research (IVDr) by NMR is its reproducibility and transferability, which enables researchers across the globe to exchange data based on SOPs embedded in the IVDr Platform solution. This allows integrated statistics on worldwide results as well as retrospective analysis of already acquired data with new analysis routines and leads to a reduction of cost. Using the IVDr by NMR platform and established standard operating procedures, it is also possible to offer remote analysis such as automatic urine quantification and lipoprotein subclass analysis on serum and plasma.
      Prof. Dr. med. Friedrich K. Trefz of University Childrens Hospital Heidelberg, Germany is in the process of developing a selective screening program for IEM using NMR as a first line method and to evaluate its efficiency to GC/MS in a routine setting of the selective screening laboratory. In this webinar, he will report of the promising first results of this program.
      What you will learn:
      1.            Usage of NMR on a standardized platform for clinical/translational research in a worldwide network
      2.            Learn about efficient NMR based mixture analysis tools that can support your work
      3.            NMR offerings for biobanks
      4.            Find out about the use of NMR in padiatric hospital routine and comparison to GC-MS

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