APR 25, 2019 10:30 AM PDT

Overcoming Complexity to Elucidate the Role of Immunoglobulin Polymorphism in the Functional Antibody Response

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Assistant Professor, Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine
    Biography
      My research interests span the fields of molecular, population, evolutionary, and disease genetics/epigenetics, using both human and animal model systems. The primary projects in my lab are currently focused on characterizing and cataloguing antibody genetic diversity in human populations, laboratory mouse strains, and the rhesus macaque. Our ultimate aim is to understand how genetic/epigenetic variation influences antibody function and the development of the immune response, and how this information can be leveraged to inform our understanding of disease susceptibility and clinical health outcomes.

    Abstract

    Recent evidence indicates that the immunoglobulin (IG) gene loci reside within the most complex and variable regions of the human genome, characterized by elevated levels of single nucleotide and gene copy number variants. This unique locus architecture has hindered the comprehensive characterization of polymorphisms in these regions, particularly using standard, short-read and array-based high-throughput genomic methods. As a result, our appreciation of the extent of haplotype variation across human populations, and the role of IG polymorphism in the immune response remains limited. This presentation will discuss efforts currently underway to establish improved genomic resources and tools that will facilitate large-scale characterization of IG genetic diversity as a means to leverage this information to improve our understanding of the functional antibody response in disease and relevant clinical phenotypes.

    Learning Objectives: 

    1. Appreciate the complexity of the human immunoglobulin gene regions and the need for improved genomic resources and tools.
    2. Understand the importance of immunoglobulin genetic variation in the antibody response and antibody-related phenotypes.


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