FEB 27, 2019 12:00 PM PST

Why Pain Control Is Good Science-The Scientific Rationale

Presented at: Drug Discovery 2019
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • University Veterinarian & Director, Laboratory Animal Resources Center, University of Texas at San Antonio
    Biography
      Dr. Perret-Gentil currently serves as University Veterinarian and Director of the Laboratory Animal Resources Center at the University of Texas at San Antonio. He is also the Attending Veterinarian of the START Center for Cancer Care in San Antonio and Lester Smith Medical Research Institute. His educational background includes a Bachelor of Science in Animal Science, a Doctorate in Veterinary Medicine, a Residency and Master of Science in Comparative Medicine and a Fellowship in Experimental Minimally Invasive Surgery. Past employment has been with the United States Army, Ethicon Endo-Surgery, Merck, University of Florida and Texas Tech Health Sciences Center.

      As of the January of 2019, Dr. Perret-Gentil has published or contributed to 60 papers, articles and abstracts. He has presented 388 special presentations at various academic and research institutions, as well as national and international meetings. He serves as ad hoc Specialist for AAALAC International, and as consultant to the government, biotechnology industry and other institutions of higher education in the United States and abroad.

    Abstract

    Too frequently the investigator will provide “scientific” reasons to justify precluding analgesics from experimental procedures that may involve more than momentary pain, often with solid literature citations.  What is too frequently dismissed is the fact that unalleviated pain itself constitutes an uncontrollable experimental variable that may, in many cases, be more impactful than the effect that analgesics could have in the experimental results.  Yes, analgesics may alter immune function as well as certain molecular pathways.  However, pain also alters immune function and has a profound influence on the hypothalamic-pituitary-adrenal axis and therefore the animal’s overall physiology.

    Through this presentation, Dr. Perret-Gentil will demonstrate the effect that unmitigated pain may have on research, and by doing so, he hopes to persuade the scientific community to give the issue of pain and analgesics greater consideration before dismissing their use within their study design.  Practical suggestions will be presented for effective control of both physical and mental pain (distress).

    Learning Objectives: 

    1. Demonstrate the effect that unmitigated pain may have on research outcomes. This effect can be more profound than pain-relieving drugs may have on research data 
    2. Provide practical suggestion for the minimization of physical and mental pain


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