FEB 03, 2016 10:30 AM PST

Panel Discussion: Promoting reproducible animal research in journal publications

  • Associate Dean of Research and Faculty Affairs, Professor of Pharmacology, Southern Illinois University School of Medicine
      Dr. Toth received her Ph.D. in Pharmacology from the University of Pittsburgh in 1980 and her DVM degree from Purdue University in 1986. Since 2004, she has held the position of Associate Dean of Research and Faculty Affairs at the Southern Illinois University School of Medicine (SIUSM), where she is also a Professor in the Department of Pharmacology. From 2000 to 2006, she was Director of the Division of Laboratory Animal Medicine at SIUSM. She has also held positions as clinical veterinarian and Associate Professor of Physiology at the University of Tennessee Memphis (1986 - 1992) and as clinical veterinarian and Associate Member in Infectious Diseases at St. Jude Children's Research Hospital (1992 - 2000).
      Dr. Toth became a Diplomate of the American College of Laboratory Animal Medicine (ACLAM) in 1991 and served for 4 years as an elected member of the ACLAM Board of Directors. She was also an elected member-at-large of the AAALAC International Executive Committee. She is also an active member of AALAS, the American Association of Laboratory Animal Science, and serves as the Editor-in-Chief for that organization's two peer-reviewed two journals - Comparative Medicine and JAALAS. Finally, she is an appointed member of an NIH study section, served on an NIEHS advisory committee, is a steering committee member and past Chair of the Group on Research Advancement and Development of the Association of American Medical Colleges, and is an advisor to the Executive Leadership In Academic Medicine (ELAM) program of Drexel University. Dr. Toth's research interests focus on the genetic modulation of sleep propensity in healthy and disease, the impact of sleep loss and diurnal disruption on susceptibility to and recuperation from infectious and inflammatory disease, and the impact of environment on research animals and data.
    • Research Scientist in Comparative Medicine; Director, Molecular, Serological and Virological Diagnostics, Yale School of Medicine
        Susan Compton received her Ph.D. in Microbiology from the Uniformed Service University of the Health Science and completed a postdoctoral fellowship at the University of Colorado. Dr Compton joined the Faculty of the Section of Comparative Medicine in the Yale University School of Medicine in 1991 and has been their Chief of the Molecular, Serological and Virological Diagnostics Unit since 1998. Susan has also held several editorial positions within the American Association for Laboratory Animal Science and is currently the Associate Editor for JAALAS. Her research is focused on the diagnosis, pathogenesis, transmission and prevention of viral infections of rodents, in particular coronaviruses, parvoviruses, noroviruses and most recently astroviruses.


      Reproducibility refers to the ability of an experiment or study to be replicated, either by the same person or group or by others working independently.  With regard to scientific publication, submitted work is presumed to be replicable by the submitting authors, consistent with the scientific method.  However, it should also be replicable by others.  To promote this, journals should require that methods sections include all information necessary to replicate each result in the manuscript.  This discussion will consider what information is necessary to accomplish that with regard to animal-based research.

      Learning objectives:

            1. How can journals promote reproducibility through publication requirements?
            2. What factors diminish the reproducibility of published research?

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