MENU
MAR 11, 2020 1:30 PM PDT

PANEL: The Neuronal Mechanisms of Human Episodic Memory: a Multidisciplinary Consortium Utilizing Human Single-Neuron Recordings

Presented at: Neuroscience 2020
Speakers
  • Professor of Neurosurgery, Director of Epilepsy and Functional Neurosurgery and Co-director of the Pituitary Center at Cedars-Sinai Medical Center
    BIOGRAPHY
  • Board of Governors Chair in Neuroscience, Director, Human Neurophysiology Research, Associate Professor, Neurosurgery, Neurology & Biomedical Sciences, Cedars-Sinai Medical Center
    BIOGRAPHY
  • Professor at Harvard Medical School and Children's Hospital and leads the Executive Function/Memory module in the Center for Brains, Minds and Machines
    BIOGRAPHY
  • Research Fellow at Kreiman Lab, Boston Children's Hospital, Harvard Medical School
    BIOGRAPHY

Abstract

Episodic memories are essential for human cognition, but the underlying neural mechanisms remain poorly understood. We utilize the opportunity to record in-vivo from human single neurons simultaneously in multiple brain areas in patients undergoing treatment for drug resistant epilepsy to study the underlying mechanisms. Supported by the BRAIN initiative, we formed a consortium among four institutions (Cedars-Sinai/Caltech, Johns Hopkins, U Toronto, and Children’s/Harvard) to maximize the use of these rare and precious opportunities to further our understanding of human memory. In this panel talk, we will highlight different aspects of our work that has become possible due to this highly interdisciplinary group of experimental and computational scientists, neurologists, neurosurgeons, and ethics experts.

We are developing a circuit-level understanding of human memory by utilizing invasive in-vivo recordings together with behavior, focal electrical stimulation, and computational modeling. We are investigating a putative circuit for human recognition memory that is composed of specific functional types of cells in the medial temporal lobe (MTL) and the medial frontal cortex (MFC). In the MTL, we are investigating the role of visually selective and memory selective cells, whereas in the MFC we are studying memory-choice cells that represent a putative readout of memories to support memory-based recognition and confidence decisions. Together, these results begin to provide a circuit-level understanding of human memory at a level of detail that is needed for the development of new treatments for memory disorders.


Show Resources
You May Also Like
JUN 28, 2022 7:00 AM PDT
JUN 28, 2022 7:00 AM PDT
Date: June 28, 2022 Time: 3:00pm (BST), 4:00pm (CET), 9:00am (CST), 7am (PST) Light-sheet microscopy is an extremely versatile imaging technique with a vast range of implementations that are...
JUN 21, 2022 6:00 AM PDT
JUN 21, 2022 6:00 AM PDT
Date: June 21, 2022 Time: 6:00am (PDT), 9:00am (EDT), 3:00pm (CEST) The global understanding and practice of medicine is currently undergoing a revolutionary change. This shift to precision...
APR 26, 2022 7:00 AM PDT
C.E. CREDITS
APR 26, 2022 7:00 AM PDT
Date: April 19, 2022 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) High-content (HC) phenotypic profiling approaches are a powerful tool to study the effect of biological, genetic, and ch...
OCT 11, 2022 8:00 AM PDT
C.E. CREDITS
OCT 11, 2022 8:00 AM PDT
Date: October 11, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Multiomic profiling of cell populations at single-cell resolution is revolutionizing scientists’ understanding o...
MAR 16, 2022 8:00 AM PDT
C.E. CREDITS
MAR 16, 2022 8:00 AM PDT
Date: March 16, 2022 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CET) Handling of potent and/or hazardous substances is commonplace in sev.....
AUG 16, 2022 11:00 AM PDT
AUG 16, 2022 11:00 AM PDT
Date: August 16, 2022 Time: 11:00am (PDT), 2:00pm (EDT), 8:00pm (CEST) Understanding genomic variation in the context of cancer is paramount to identifying disease drivers and informing pers...
Loading Comments...
Show Resources