JUN 21, 2018 1:30 PM PDT

Pharmacogenetics in Psychiatry

Speaker
  • Head of the Pharmacogenetics Research Clinic at the Campbell Family Mental Health Research Institute at CAMH, and Associate Professor in the Department of Psychiatry at the University of Toro
    Biography
      Dr. Mueller earned his MD at the University of Bonn (Germany) and completed his residency training in Psychiatry at the Charité University Clinic in Berlin. In 2008, he has been appointed at the University of Toronto (Department of Psychiatry), and as Clinician Scientist at CAMH. At the same time, he became Head of the Pharmacogenetics Research Clinic at CAMH which is one of the first of its kind worldwide to develop clinical implementation strategies (e.g., Müller DJ et al., 2013; PMID:24151801). Dr. Mueller's overall research goals are to investigate genetic causes of response and side effects to psychiatric medications. This line of research aims to significantly improve treatment of psychiatric conditions and to lessen the burden of medication side effects and to avoid negative drug-drug interactions. In addition, he is actively involved in developing pharmacogenetic guidelines for physicians and patients and is affiliated with the Clinical Pharmacogenetics Implementation Consortium (Caudle et al., 2014; PMID: 24479687). For more information, visit www.pharmacogenetics.ca For a complete publication record, see:
      https://scholar.google.de/citations?user=lnbto4AAAAAJ&hl=de

    Abstract

    There is robust evidence supporting strong association with CYP450 (Phase 1) enzymes and influence on drug levels (affecting response & side effects in many cases) with many psychotropic antidepressants and antipsychotics. Genetic implementation strategies for Phase-1 enzymes increasingly being adopted globally and genetic tests might become available specifically to predict specific side effects.


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