NOV 08, 2019 08:00 AM PST

Polygenic Risk Score analysis for Alzheimer's disease risk

Speakers
  • CEO, Cytox Ltd
    Biography
      Richard Pither has been involved in the development of diagnostic and therapeutic pharmaceutical products for more than 25 years. He has been CEO at Cytox for the past 7 years, a precision medicine working on developing and commercialising a new diagnostic technology for assessing Alzheimer's Disease risk. Prior to Cytox, Richard has held senior R&D and leadership positions in global pharmaceutical companies including GE Healthcare/Amersham plc, Lorantis and UCB-Celltech. During this time, he was involved in the development of a novel 18F-PET radiopharmaceutical for imaging amyloid deposition in the brains of Alzheimer's disease patients.

    Abstract:
    DATE:  November 8, 2019
    TIME:  8:00am PT, 11:00am ET
     
    The utility of Polygenic Risk Scores (PRS) is gaining researchers' attention for identifying individual genetic risk and disease risk prediction in Alzheimer's Disease (AD) at both the early and pre-symptomatic stages of the disease. genoSCORE™ combines Cytox's proprietary technologies variaTECT™, a proprietary single nucleotide polymorphism (SNP) profiling array built on the Axiom platform from Thermo Fisher Scientific, with the SNPfitR™ analytical and interpretive software incorporating algorithms developed in partnership with Cardiff University, to give a PRS that identifies any individual's genetic risk of developing AD from blood or saliva-extracted DNA. This can help in patient stratification for clinical trial research to develop targeted treatments for AD.
     
    Learning Objectives:
    • Select the highest risk APOE3/E4 subjects mostly likely to develop AD
    • Identify highest/low risk APOE3/E3 subjects for inclusion/exclusion in clinical studies
     
     
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