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SEP 17, 2020 9:00 AM PDT

Preclinical Optical Imaging of Infectious Diseases

Sponsored by: PerkinElmer
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Divisional VP, Biology Solutions at PerkinElmer
    Biography

      Kevin Francis began his scientific career in 1987 as a viral research scientist, developing FMDV vaccines for Wellcome in the UK. In 1990 he returned to academia to pursue a PhD in bacterial pathogenesis at University of Edinburgh, followed by 4 years as a postdoctoral scientist at University of Nottingham and 2 years as an Assistant Professor at the Technical University of Munich. In 1999 he joined Xenogen Corporation, now part of PerkinElmer, as Director of Infectious Disease Research, before becoming Head of Biology R&D. He is currently a Fellow within this organization, helping to direct scientific innovation both internally and externally through collaborative research with PE's extensive customer base. In February 2008 Kevin was awarded an Honorary Professorship in the Department of Surgery at the University Medical Center Groningen, and currently serves as a Visiting Professor in the Department of Orthopaedic Surgery at UCLA and in the Department of Microbial Pathogenesis and Immunology at Texas A&M.


    Abstract

    PerkinElmer is a global leader in the development of instrumentation and probes for small animal non-invasive imaging, including optical and µCT imaging. Through optical imaging, we have developed a technology which allows biological processes, including gene expression that is temporally and spatially defined, to be non-invasively monitored both longitudinally and in real-time. Genes encoding optical reporters, luciferases and fluorescent proteins, are engineered into cells and pathogens (e.g., bacteria, viruses), or directly into animals (e.g., monitoring host responses) to enable the generation of light that can be visualized through the tissues of a live animal. PerkinElmer has optimized this technique to allow true three-dimensional optical imaging and tomographic multimodality imaging (e.g., through co-registration of optical imaging with µCT and MRI). Furthermore, this technique is equally applicable to imaging of fluorescent dyes and particles, allowing fluorescently tagged biological events (e.g., tracking of antibodies, peptides and viral capsids) to be monitored both independently and in combination with genetically tagged events. An overview of optical imaging in viral and bacterial disease research will be presented, showing how this approach can be used to refine and improve fundamental biological research, as well as drug development and clinical translation strategies.

    Learning Objectives:

    1. Understand the principle of non-invasive preclinical optical imaging as it relates to infectious disease research

    2. Recognize different molecular imaging techniques for visualizing host-pathogen interactions


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